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Control of Myosin (Muscles) by Kinases Sol M. Gruner, Cornell Univeristy, DMR 0936384

Control of Myosin (Muscles) by Kinases Sol M. Gruner, Cornell Univeristy, DMR 0936384.

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Control of Myosin (Muscles) by Kinases Sol M. Gruner, Cornell Univeristy, DMR 0936384

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  1. Control of Myosin (Muscles) by KinasesSol M. Gruner, Cornell Univeristy, DMR 0936384 Intellectual Merit: In order for muscles to generate contractile force, myosin molecules must be assembled into filaments, and the assembly is regulated by proteins called myosin heavy chain kinases (MHCK's). Jia’s group used CHESS to get the first detailed look at the structure of several complexes of the MHCK A catalytic domain (A-CAT), providing new insights into the regulatory functions of a-kinases. "Crystal Structure of the α-kinase Domain of Dictyostelium Myosin Heavy Chain Kinase A"; Q. Ye, S.W. Crawley, Y. Yang, G.P. Côté, and Z. Jia, Science Signaling (2010), Vol. 3, ra17. Journal cover image showing the newly determined electrostatic potential surface of A-CAT. CHESS DMR-0936384 2010_1

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