NSF DAYS at Binghamton University Directorate for Biological Sciences National Science Foundation

1. NSF DAYS at Binghamton University Directorate for Biological Sciences National Science Foundation Diane M. Witt, PhD. www.NSF.gov

2. National Science Board Office of Inspector General National Science Foundation Director Deputy Director • Office of the Director • Legislative & Public Affairs • Equal Opportunity Programs • General Counsel • Integrative Activities • Polar Programs • Directorates • Biological Sciences • Computer & Information Science & Engineering • Education & Human Resources • Engineering • Geosciences • Mathematical & Physical Sciences • Social, Behaviorial & Economic Sciences • Offices • Budget, Finance & Award Management • Information & Resource Management

4. Biological Sciences Directorate Vision Inspiring research and education at the frontiers of the life sciences Mission To enable the discoveries for understanding life

5. Division of Environmental Biology (DEB) Molecular & Cellular Biosciences (MCB) Ecological Biology Biomolecular Systems Ecosystem Science Cellular Systems Population & Evolutionary Processes Genes & Genome Systems Systematic Biology &Biodiversity Inventories Emerging Frontiers (EF) Division Directorate for Biological Sciences Division of Biological Infrastructure (DBI) Integrative Organismal Systems (IOS) Divisions HumanResources Neural Systems Research Resources Developmental Systems Clusters BehavioralSystems Physiological & Structural Systems

6. Division of Biological Infrastructure (DBI) • Supports varied activities that provide the infrastructure for contemporary research in biology • Research Resources • Databases • Curatorial improvement, computerization of research collections • Living stock collections • Major items of multi-user instrumentation • Development of new instrumentation • Research facilities at biological field stations, marine labs • Human Resources • Undergraduate research and mentoring in biology • Postdoctoral research fellowships in biology

7. Integrative Organismal SystemsIOS Supports research focusing on an integrative understanding of organisms. • Understand why organisms are structured the way they are and function the way they do. • Innovative applications of systems biology approaches (i.e., combined experimentation, computation, modeling) • New conceptual and theoretical insights and predictions that may be experimentally verified

8. Integrative Organismal Systems IOS Neural Systems Cluster Organization • How do genetics, developmental processes, and experience/environment interact to produce structure and function? Activation • Information extraction from the environment and integration within the organism to form a decision, perception, or action Modulation • Robust emergent properties that underlie adaptive behavior, learning, and complex social interactions

9. Integrative Organismal Systems IOS Developmental Systems Cluster Plant, Fungal, and Microbial Developmental Mechanisms Animal Developmental Mechanisms • Understanding how interacting developmental processes lead to emergent properties and complex phenotypes Evolution of Developmental Systems • Discovering the developmental processes shared by all organisms and those singular ones that produce diversity

10. Integrative Organismal Systems IOS Behavioral Systems Cluster Animal Behavior • Social and reproductive behavior • Behavioral ecology and physiology • Neural and hormonal mechanisms • Development, function, and mechanisms • Evolutionary history

11. Integrative Organismal Systems IOS Physiological & Structural Systems Symbiosis, Defense and Self-recognition • Processes and structures that mediate intimate interactions between two or more organisms Organism – Environment Interactions • Structures and processes that affect organismal performance under routine, changing, or stressful environmental conditions Processes, Structures and Integrity • Structural and functional properties and interactions that orchestrate daily existence

12. Division of Environmental Biology (DEB) • DEB supports fundamental research on: • origins, functions, relationships, interactions, and evolutionary history of populations, species, communities, and ecosystems. • Scientific emphases include systematic biology, biotic surveys & inventories, molecular genetic and genomic evolution, mesoscale ecology, conservation biology, global change, and restoration ecology.

13. Environmental Sciences (DEB) • Ecological Biology • Ecosystem Science • Population & Evolutionary Processes • Systematic Biology & Biodiversity Inventories

14. Molecular & Cellular Biosciences (MCB) Biomolecular Systems • Structure, function, dynamics, interactions, and interconversions of biological molecules • Individual macromolecules to the large-scale integration of metabolic and energetic processes • Development of cutting-edge technologies • Mechanistic studies of the regulation and catalysis of enzymes and RNA • Higher-order characterization of the biochemical processes by which all organisms acquire, transform, and utilize energy from substrates

15. Cellular Systems (MCB) • Cellular Systems Cluster focuses on the structure, function, and regulation of plant, animal and microbial cells, and their interactions with the environment and with one another. • Areas supported include studies of the structure, function, and assembly of cellular elements, such as the cytoskeleton, membranes, organelles, intracellular compartments, intranuclear structures, and extracellular matrix, including eukaryotic and prokaryotic cell walls and envelopes.

16. Genes & Genomes Systems (MCB) • Genomes and genetic mechanisms in all organisms, whether prokaryote, eukaryote, phage, or virus. • The structure, maintenance, expression, transfer, and stability of genetic information in DNA, RNA, and proteins and how those processes are regulated. • Genome organization, molecular and cellular evolution, replication, recombination, repair, and vertical and lateral transmission of heritable information. • Processes that mediate and regulate gene expression, such as chromatin structure, epigenetic phenomena, transcription, RNA processing, editing and degradation, and translation.

17. Directorate for Biological Sciences

18. BIO 2009 Priorities Life in Transition Microbial Systems Synthetic Biology Adaptive Systems Technology

19. Funding Opportunities in BIO Life in Transition (LiT)

20. OriginsHow, where and when did life on Earth begin? Open system chemistry Self-replication DNA World RNA World H2 + CO2 => [ HCO ]n Self-sustaining biochemistry How did the biological complexity of life emerge from pre-biotic chemistry and geochemistry? Basic elements

21. Energy How is energy obtained and used by living systems to sustain life? Au PS I Ag Applied Photosynthes e- e- photon e- Assemble the basics e- Barry Bruce (UTN), NSF/EF -/+ Chloroplasts Understanding natural energy transduction systems will inspire the development of biology-based technologies capable of delivering sustainable, renewable, efficient energy.

22. Adaptation Transformations and Transitions in the Story of Life What will survive, and how? Diversity Understanding life’s resilience and adaptation will reduce uncertainty about the future of life on Earth in response to global climate change. Changes

23. Transdisciplinary Interdisciplinary Multi-disciplinary Disciplinary Life Sciences In Transition

24. Funding Opportunities in BIO Microbial Systems in the Biosphere (MSB) Replaces Microbial Observatories and Microbial Interactions and Processes (MO/MIP) Solicitation

25. Microfluidic System RNA Evolution Membrane Encapsulation Brian Paegel and Gerald Joyce Scripps Research Inst. Are There Alternative Routes to Life? ? Genome Stability Synthetic BiologyWhat are the indispensable requirements for life? • What are: • The physical rules for cell membrane assembly? • The minimum gene set required to sustain life? • The fundamental requirements for genome stability?

26. Synthetic Biology

27. Adaptive Systems Technology Closing the Loop of Theory, Observation, Experimentation, and Technology D. E. Koditschek, ESE Department, University of Pennsylvania

28. Funding Opportunities in BIO Solicitations Special programs with specific guidelines, deadlines, cycles (annual, biennial), etc.

29. Selected Solicitations • Assembling the Tree of Life (AToL) • Constructing a universal Tree of Life for all 1.7 million named species of organisms on earth • Due Date: March (new solicitation forthcoming)

30. Selected Solicitations 2010 Project (will be phased out as a separate solicitation) • Determine the function of all genes in Arabidopsis thaliana by the year 2010 • Due Date: Feb. 19, 2009 (09-514)

31. Selected Solicitations Research Coordination Networks in Biological Sciences (RCN) • Encourage and foster interactions among scientists. Create new research directions or advance a field. • Due Date: June 29, 2009 (06-567)

32. Selected Solicitations Research Coordination Networks- Undergraduate Biology Education (RCN-UBE) • Similar to RCN but focuses on improving Biology Education • Due Date: June 29, 2009 (06-567)

33. Selected Solicitations Research Coordination Networks- Undergraduate Biology Education (RCN-UBE) • Similar to RCN but focuses on improving Biology Education • Due Date: June 29, 2009 (06-567)

34. Selected Multidisciplinary Programs Ecology of Infectious Diseases (BIO, GEO, SBE, NIH) • Discovery of predictive models and principles governing the transmission dynamics of disease agents. • Due Date: Dec. 10, 2008 (08-601) Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (BIO,EHR,MPS) • Enhancing undergraduate education and training at the intersection of the biological and mathematical sciences. • Due Date: Feb. 12, 2009 (08-510)

35. Developing Expertise and Broadening Participation Funding Opportunities in NSF/BIO

36. Developing Expertise andBroadening Participation High School Students Research Assistantships to High School Students (RAHSS) Supplement(06-027)

37. Developing Expertise andBroadening Participation Undergraduates Research at Undergraduate Institutions (RUI) Same target date as core programs (announcement 00-144) Research Experience for Undergraduates (REU) Sites (June 5, 2009) and Supplements (contact PD) (07-569) Undergraduate Research and Mentoring in the Biological Sciences (URM) Due Date: March 3, 2009 (06-591) Alan Savitzky (asavitzk@nsf.gov) Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (UBM) Due Date: Feb. 12, 2009 (08-510) Nancy Huntly (nhuntly@nsf.gov)

38. Developing Expertise andBroadening Participation Graduate Students Graduate Research Fellowships (GRFP) (08-593). Due date: Nov. 7, 2008 Education and Human Resources Directorate. NSF-wide program Doctoral Dissertation Improvement Grants (DDIG) (08-564). Due date: Third Friday in November. DEB and Behavioral Cluster in IOS (ddig-deb@nsf.gov; ddig-ios@nsf.gov) Integrative Graduate Education and Research Traineeship (IGERT) (new solicitation soon). Due date: April, 2009 Education and Human Resources Directorate. NSF-wide program

39. Developing Expertise andBroadening Participation Postdoctoral Fellows Postdoctoral Research Fellowships in Biology (GRFP) (07-580). Due date: Nov. 2, 2009 Division of Biological Infrastructure • Broadening Participation of Under-represented Groups in Biology Carter Kimsey (ckimsey@nsf.gov) • Biological Informatics Peter McCartney (pmccartn@nsf.gov) Minority Postdoctoral Research Fellowships and Supporting Activities (06-586). Due date: First Monday in November BIO and SBE BIO: Carter Kimsey (ckimsey@nsf.gov)

40. Faculty and Teachers Developing Expertise andBroadening Participation Faculty Early Career Development Program (CAREER) (08-557). Deadline: July 21, 2009 Untenured Assistant Professors Mary Chamberlin (mchamber@nsf.gov) Research Initiation Grants to Broaden Participation in Biology (RIG BP) (09-501) Deadline: Jan. 12, 2009 New investigator, new faculty Carter Kimsey (ckimsey@nsf.gov) Research Opportunity Awards (ROA) (07-041) Supplement Research Experience for Teachers (RET) (05-524) Supplement

41. Realities: Funding Realities 2009 Request

42. Call Your PROGRAM DIRECTOR

43. Summary and Advice Read the Grant Proposal Guide

44. Improve the health of the Nation by conducting and supporting research: in the cause, diagnosis, prevention, and cure of human disease. National Institutes of Health NIH______________________

45. Mission: To promote the progress of science; to advance the national health, prosperity and welfare; to secure national defense (NSF Act 0f 1950). Vision: Advancing discovery, innovation, and education beyond the frontiers of current knowledge, and empowering future generations in science and engineering.

46. NSF Online FastLane 15 Pages Target Dates,deadlines Suggested Reviewers FASTLANE NIH Grants.gov 25 Pages 3 Deadlines eCommons Proposal Submission FASTLANE

47. NSF Advisory Panels Ad Hoc Reviews NIH Study Sections Review System________________________

48. NSF All proposals discussed High Priority Medium Priority Low Priority Non-competitive NIH “Streamlined” Priority score Percentile Funding line Review System________________________

49. Merit Review Criteria Best ideas from the most capable people, determined by competitivemerit review. • Intellectual merit • Broader impacts

50. Transformative Transformative Discoveries