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Update from the I4C International Data Coordinating Centre

Update from the I4C International Data Coordinating Centre. Gabriella Tikellis (PhD) Murdoch Childrens Research Institute 6 th International I4C Meeting, IARC 5-6 th October, 2013. I4C member cohorts. MoBa - Norway 109,981. DNBC - Denmark 101,042. GEHBC – Germany 200,000.

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Update from the I4C International Data Coordinating Centre

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  1. Update from the I4C International Data Coordinating Centre Gabriella Tikellis (PhD) Murdoch Childrens Research Institute 6th International I4C Meeting, IARC 5-6th October, 2013

  2. I4C member cohorts MoBa - Norway 109,981 DNBC - Denmark 101,042 GEHBC – Germany200,000 ALSPAC - UK 14,042 ELFE – France20,000 BCS - UK100,000 CFCS – China 300,000 CPP - USA 60,000 Bradford - UK10,000 JECS - Japan 100,000 NINFEA – Italy7,500 JPS - Israel 92,408 Wuhan - China120,000 BDSS - China 247,831 NCS - USA 100,000 CIHS - Brazil100,000 Murdoch Childrens Research Institute I4C International Data Coordinating Centre MCRI - VIC100,000 TIHS 10,627

  3. Role of the IDCC

  4. Coordinate the transfer of cohort data to a central location (i.e. MCRI) Maintain and ensure the data is kept secure In collaboration with cohort representatives, work on the cleaning,validation and harmonization of variables from each dataset Develop pooled datasets for analysis Provide statistical support where required Work with cohorts, Working Groups and other members to assist and facilitate the various research and day-to-day activities Provide scientific input into the development of research proposals I4C draft policies_March2013

  5. Welcome to our Biostatisticians Prof Stanley Lemeshow Dr Gary Phillips Center for Biostatistics

  6. Childhood cancer cases

  7. Total number of cancer cases at I4C IDCC:Oct 2013based on all live births (545) MoBa: Results from latest linkage to cancer registry in May 2013, found 127 cases of CC. Awaiting details on cancer types to be made available to IDCC

  8. Progress in last 12 months • Ascertainment of follow-up years for each child • Established age of child at last contact time - for cancer cases and non-cancer subjects across 6 cohorts • Significant amount of work carried out to determine amount of follow up for each subject • Communication with cohorts to establish dates of linkage with cancer registries or last dates of contact

  9. Transfer of questionnaire data

  10. 6 cohorts contributing data to the pooled dataset • ALSPAC, UK • CPP, USA • DNBC, Denmark, • JPS, Israel • MoBa, Norway • TIHS, Australia

  11. Tally of available data at IDCC 380,427- mothers and babies* * Includes 10% subsample from DNBC and MoBa

  12. Pooled variables provide a ‘core’ dataset which we have used to examine birth weight and childhood cancer association

  13. Pooled dataset- Birth weight X = data not collected ? = to be verified Not all variables included in final models, Variables included were focused on prenatal time period

  14. Birth-related variables X = data not collected

  15. Focus on additional variables X = data not collected ? = still being worked on Cleaning and harmonizing of data on previous fetal loss required over 4 months of work to verify data and document the decisions made

  16. New exposure data

  17. Next steps • Incorporate additional cases of CC from updated linkages to cancer registries (e.g. MoBa) or new cohorts • Create new datasets for analysis of other hypotheses to be examined : • Parity and birth order • Previous fetal loss • Parental age • Identify what data is available on exposures relating to new areas of interest such as infections

  18. Web-based Data Pooling Application at IDCC(developed by Luke Stevens)

  19. Data Pooling Application • MCRI’s secure e-Research portal • Restricted access • I4C team only • Can restrict user access at dataset level • Ongoing development

  20. Data Pooling Application • Run a query • Select variables to download • Select from any dataset • Database joins the datasets returning a combined data file

  21. Data Pooling Application • Select variables to download • Select from any dataset • Database joins the datasets returning a combined data file

  22. Data Pooling Application • Edit or Save your query • Download • Raw data file

  23. Information on I4C • NIH/NCI- I4C portal https://communities.nci.nih.gov/i4c/default.aspx • MCRI- website http://www.mcri.edu.au/research/international-partnerships-collaborations/i4c • National Children’s Study website http://www.nationalchildrensstudy.gov/research/internationalinvolvement/pages/default.aspx

  24. Many thanks to ... DNBC Sjurdur Olsen Jorn Olsen Marin Ström Charlotta Granström JPS Ora Paltiel Elena Polanker MoBa Camilla Stoltenberg Siri Eldevik Håberg Therese Bakke • MCRI • Terry Dwyer • Luke Stevens • Karen Lamb • ALSPAC • Jean Golding • Kate Northstone • CPP • Mark Klebanoff • Logan Spector • NIH/NCI • Martha Linet • Somdat Mahabir

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