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Tay Sachs and Sickle Cell

Tay Sachs and Sickle Cell. Similarity genetic mutation Both recessive Premature death of cells Mutation of one protein Only in racial groups. Differences Sickle cell messes with your blood T ay sachs messes with your brain Tay sachs you end up dying and no cure

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Tay Sachs and Sickle Cell

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  1. Tay Sachs and Sickle Cell Similarity • genetic mutation • Both recessive • Premature death of cells • Mutation of one protein • Only in racial groups • Differences • Sickle cell messes with your blood • Taysachs messes with your brain • Taysachs you end up dying and no cure • Sickle cell has a cure no dying

  2. Four Forces when amino acids are placed in water

  3. Van der Waals • Natural stickiness of atoms • Caused by the protons and electrons attracting to one another

  4. Electrostatic charge • Some amino acids are ions which can be positive or negative (positive and negative attract) • Neutrons and neutral no charge

  5. S-S bonds (sulphur-sulphur bonds • Sulphur attracts to itself • Two cystines will stick together from a sulphur bridge • Sulphur bridge- the whole chain would have to follow and fold s that the to sulphurs can stick

  6. Hydrogen bonds • Hydrogen bonds only occur in water • All amino acids are affected by hydrogen bonds when in water • Water has a negative and positive charge.

  7. Hydrophilic • Root words- Hydro-water Phil-loving Water loving (polar) (have positive and negative charges) Hydrophilic amino acids • Thr • Asn • Gln • Ser • Arg • Lys • His • Asp • Glu • Neutral • Tyr • Cys • Met

  8. Hydrophobic • Root words- Hydro-water phobic-fear Fear of water (nonpolar)(no charge-neutral) Hydrophobic • Phe • Val • Lle • Leu • Pro • Aly • Gly • Trp • Neutral • Tyr • Cys • Met

  9. Effects of environment on proteins • Alanine (hydrophobic) this is in water- first this amino acid was dry but in water they clump together. • Alanine in oil spread out and try to get exposed • Glutamic acid (hydrophilic) when in water it spreads out. • In oil this amino acid clumps together.

  10. Glutamic acid and Valine Glutamic acid in water will stretch out in a long line Valine in water would scrunch up in a small ball and clump together

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