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Single-centre retrospective analysis (Turkey; 2004-2010)

1 of 2. Impact of ribavirin and corticosteroids on mortality in patients infected with Crimean-Congo haemorrhagic fever (CCHF) virus. Single-centre retrospective analysis (Turkey; 2004-2010) N=281 patients with confirmed diagnosis of CCHF

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Single-centre retrospective analysis (Turkey; 2004-2010)

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  1. 1 of 2 Impact of ribavirin and corticosteroids on mortality in patients infected with Crimean-Congo haemorrhagic fever (CCHF) virus Single-centre retrospective analysis (Turkey; 2004-2010) N=281 patients with confirmed diagnosis of CCHF Revision of existing severity scoring index*: criteria: Platelet count Bleeding Fibrinogen Activated partial thromboplastin time Somnolence Overall mortality rate: 23/281 = 8% Dokuzoguz B. ECCMID 2013 abs. O335 *Ergonul O et al. Clin Microbiol Infect 2006;12:551-4.

  2. 2 of 2 Impact of ribavirin and corticosteroids on mortality in patients infected with Crimean-Congo haemorrhagic fever (CCHF) virus • Multivariable regression analysis (adjusted for gender, age, days from onset of symptoms, ribavirin and steroid use): • Effect of ribavirin and corticosteroids on mortality (χ2 test adjusted for severity scoring index): • Ribavirin: Significant decrease of mortality in moderately severe patients • Steroids: Significant decrease of mortality in severe patients Ribavirin may decrease mortality in moderately ill patients with CCHF, while steroids may be especially beneficial for severe patients (with severity defined by a revised severity scoring index) Dokuzoguz B. ECCMID 2013 abs. O335

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