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Medical Imaging Resource Center (MIRC) Research Applications

Medical Imaging Resource Center (MIRC) Research Applications. J. Jeffrey Carr, MD, MSCE, FACC Division of Radiological Sciences, Internal Medicine - Cardiology & Public Health Sciences. No disclosures Support through grants from NIH/NHLBI/NIAMS/NIDDK & WFUHS. Presenter Disclosure Information.

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Medical Imaging Resource Center (MIRC) Research Applications

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  1. Medical Imaging Resource Center (MIRC)Research Applications • J. Jeffrey Carr, MD, MSCE, FACC • Division of Radiological Sciences, Internal Medicine - Cardiology & Public Health Sciences No disclosures Support through grants from NIH/NHLBI/NIAMS/NIDDK & WFUHS

  2. Presenter Disclosure Information J. Jeffrey Carr DISCLOSURE INFORMATION: The following relationships exist related to this presentation: None UNLABELED/UNAPPROVED USE:The following products are not labeled for the use under discussion or are still investigational: None

  3. Imaging Research • Established and novel phenotypes • Clinical and subclinical disease • Numerous modalities (DICOM format) • Small to Large studies • 10,000+ • Multiple exams (change over time) • Multiple field centers across the world • Relatively Short time periods • Most projects < 5 years duration

  4. How Does MIRC support • Transfer of image and other information? • Participant identification & confidentiality? • Data Cleaning (i.e. fixing mistakes)? • Quality Control / Data Tracking?

  5. Challenges • Large amounts of data • CT: ~ 400 images [200 MB] • CTA ~ 2,500 images/study [1.25 GB] • 6,000 exams = 1.2 -7.5 TB • Complexity of data management • Quality Control • Confidentiality

  6. Imaging Research at Wake Forestusing MIRC toolkit • Women's Health Initiative Memory Study (NIH) • Coronary Artery Risk Development in Young Adults (NHLBI’s CARDIA) • Women's Health Initiative (WHI-CACS) • Carotid Atherosclerosis MRI Progression • Alzheimer's Disease Neuroimaging Initiative • Crash Injury Research & Engineering Network

  7. Network Security • Each Institution has established security procedures and personnel • Electronic Transfers • Security issues at each end • Media (CD/DVD) + Courier • Liabilities related to physical media

  8. Internet DICOM imaging analysis workstation CT System

  9. Internet Firewall Firewall X X DICOM imaging analysis workstation Remote CT

  10. Internet Remote MIRC FieldCenter DICOM import to HTTP export DICOM imaging analysis workstation Remote CT Firewall Firewall

  11. Internet Remote MIRC FieldCenter DICOM import to HTTP export HTTP import to DICOM export HTTP WFUSM MIRC DICOM DICOM imaging analysis workstation Remote CT Firewall Firewall

  12. Internet Remote Network Remote Network WFUSM firewall #1 Remote MIRC FieldCenter HTTP import to DICOM export (MIRC IN to Titan) HTTP import on http://182.158.1.101:8443/CARDIA_WFU/import/doc DICOM export from CARDIA_WFU@192.158.1.101:3333 to CARDIA_XX (Titan) MIRC software WFUSM firewall #2 RAID storage WFUSM MIRC in DMZ MIRC IN: 182.158.1.101: port 8443 (ext) 192.158.1.101: port 104,3333,8443 (int) WFUSM DICOM research server Titan: 192.168.1.110: port 104 AE TITLE: CARDIA_XX CARDIA year20 data flow UIC/USF to DMZ WFUSM MIRC UIC CT USF CT

  13. Remote Network FileSender Loaded on WFUSM MIRC receiver Calcium scoring workstations Remote MIRC FieldCenter Internet WFUSM firewall #1 WFUSM MIRC receiver RAID storage WFUSM firewall #2 WFUSM DICOM research server WFUSM MIRC in DMZ WHI data flow UIC USF UPMC UMN CDs sent via from 26 Field Centers

  14. WFUSM Firewall TeraRecon imaging analysis workstation GE Advantage imaging analysis workstation Internet Remote MIRC FieldCenter WFUSM MIRC in DMZ Remote Network WFUSM Network Internet External RAID backup system MIRC within WFUSM firewall External Ultra SCSI3 WFUSM research DICOM server WFUSM NAS WFUSM MIRC hardware configuration Remote CT Remote MR

  15. Exabyte VXA-2 Autoloader (1 x 10) • NAS (network attached storage) • EMC • Fiber attached • Raid5+1 configuration WFUSM NAS Sony external DL/DVD±RW drive • Research archiving server • VXA-2 Tape (80/160GB) • DVD-R (4.7/8.5GB) WFUSM research archiving server WFUSM DICOM research images Long term storage and archiving • External attached RAID • Ultra SCSI-3 • Raid5 configuration WFUSM MIRC receivers External RAID backup system WFUSM Network WFUSM research DICOM server

  16. Identification of Research Participants • Name? (HIPAA Concerns) • De-identification • Study identifiers • Clinical HIS/RIS issues

  17. How to fix mistakes & Problems? • Study identifiers • Missing / inconsistent / problematic DICOM fields • Clinical HIS/RIS issues

  18. MIRC DICOM Editor

  19. MIRC software tools • FieldCenter • Application to receive DICOM images from an imaging modality • DICOM export images from remote sites to reading center via internet • Anonymize/de-identify/modify DICOM images • DicomEditor • Modification and correction of DICOM header • Powerful anonymization/de-identification tool • Batch modifying application • FileSender • DICOM export corrected images back to workstation/DICOM server • DICOM export images from local media and network drives • MOD • CD-rom/DVD-rom • Hard drive • Other misc media formats

  20. Conclusions • MIRC supports secure transfer of images and other data • MIRC enables central participant de-identification • MIRC facilitates Data tracking, Cleaning & Quality Control • MIRC greatly simplifies research management

  21. Special Thanks to: Josh Tan (Formerly WFUSM now TeraRecon) John Perry (RSNA) Peter Santago, Ph.D. (WFUSM) Kerry M. Link, M.D. (WFUSM) Bob Ellison (WFUSM) Nick Bryan, M.D., Ph.D. (UPenn) Lisa Desiderio (UPenn) DengFeng Liu (UPenn) Steve Moore (Mallinckrodt) Acknowledgements: Wake Forest University School of Medicine (Radiology and Biomedical Engineering) Wake Forest University Health Sciences University of Pennsylvania Winston-Salem State University

  22. Thank You! Division of Radiologic Sciences and Public Health Sciences www.wfubmc.edu/imagelab

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