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Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

Featured Article :. Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome. Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet Kaur, Ph.D., Alexander Chien, B.S., Sridevi Devaraj, Ph.D. Diabetes Care Volume 35: 900-904 April, 2012. Study Objective.

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Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

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  1. Featured Article: Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet Kaur, Ph.D., Alexander Chien, B.S., Sridevi Devaraj, Ph.D. Diabetes Care Volume 35: 900-904 April, 2012

  2. Study Objective • Metabolic syndrome (MetS) is a proinflammatory state, but there is a paucity of data on cellular inflammation in MetS • Toll-like receptors (TLRs) are classical pattern recognition receptors of the innate immune response • Aim of study was to compare monocyte TLR2 and TLR4 between MetS patients and control subjects Jialal Iet al. Diabetes Care 2012;35:900-904

  3. Study Design • Fasting blood obtained for TLR expression and activity • Participants with MetS but no CVD or diabetes compared to control participants Jialal Iet al. Diabetes Care 2012;35:900-904

  4. Jialal Iet al. Diabetes Care 2012;35:900-904

  5. Jialal Iet al. Diabetes Care 2012;35:900-904

  6. Jialal Iet al. Diabetes Care 2012;35:900-904

  7. Conclusions • Both TLR2 and TLR4 expression and activity are increased in the monocytes of patients with MetS • This could contribute to increased risk for diabetes and CVD with MetS Jialal Iet al. Diabetes Care 2012;35:900-904

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