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Y. Lincoln. M.H.C. TLRs. Presenting... an antigen!. 200. 200. 200. 200. 200. 400. 400. 400. 400. 400. 600. 600. 600. 600. 600. 800. 800. 800. 800. 800. 1000. 1000. 1000. 1000. 1000.

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  1. Y Lincoln M.H.C. TLRs Presenting... an antigen! 200 200 200 200 200 400 400 400 400 400 600 600 600 600 600 800 800 800 800 800 1000 1000 1000 1000 1000

  2. Most antibodies are found in the this group of globulins which are the 3rd fastest migrating.

  3. What are gamma globulins?

  4. IgG molecules are cleaved by this enzyme to form 2 Fab fragments and 1 Fc fragment.

  5. What is papain?

  6. These two antibodies are the best complement activators.

  7. What are IgM and IgG?

  8. This heavy chain is expressed on the surface of pre-B cells, associated with surrogate light chains, and is absent in an autosomal recessive form of agammaglobulinemia.

  9. What is the μ heavy chain?

  10. This is the CDR with the most variability.

  11. What is CDR3?

  12. He killed Lincoln.

  13. Who is John Wilkes Booth?

  14. What are the first 6 words of the Gettysburg Address?

  15. What is ‘Four score and seven years ago’?

  16. In number order, he was this president of the US.

  17. What is 16th president?

  18. Lincoln belonged to this political party.

  19. What is the Republican party?

  20. Lincoln was born in this state.

  21. What is Kentucky?

  22. This is the name of the set of MHC alleles present on each chromosome.

  23. What is a haplotype?

  24. These two chains make up MHC class I.

  25. What is an α chain and β2 microglobulin?

  26. Peptides are transported into the ER for Class I loading by this molecule

  27. What is TAP?

  28. This segment of class II molecules contain the binding site for CD4.

  29. What is the β2 segment?

  30. This cytokine is encoded in the MHC

  31. What is TNF α, lymphotoxin α or lymphotoxin β?

  32. This TLR binds LPS.

  33. What is TLR4?

  34. These 4 TLRs are expressed on endosomes.

  35. What are TLRs 3, 7, 8, 9?

  36. This TLR does not signal through MyD88.

  37. What is TLR3?

  38. Polymorphisms in this “CARD carrying” member of the NLRs is associated with Crohn’s disease.

  39. What is NOD2?

  40. This enzyme is induced after ligation of TLRs and function to reduce oxygen in reactive oxygen species.

  41. What is NADPH (or phagocyte) oxidase?

  42. It is an accessory molecule on this cell that binds to CD80/CD86.

  43. What is CD28 on T cells?

  44. Cytokine receptors signal through this pathway.

  45. What is Jak/STAT?

  46. In TCR signaling, Lyk phosphorylates ITAMs on ζ chains in order to provide a docking site for this tyrosine kinase.

  47. What is ZAP-70?

  48. The B cell equivalents of Lck/ZAP-70 are these.

  49. What are Lyn/Syk?

  50. After IP3 mediated calcium liberation from the ER, STIM1 induces the opening of this channel to allow calcium influx into the cell.

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