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Looking only at 25-week data. Hierarchical clustering -> two clusters which are up (yellow) in KO tumor and not (blue) in WT tumor. Select 389 genes (marked in green in the heat maps)
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Looking only at 25-week data • Hierarchical clustering -> two clusters which are up (yellow) in KO tumor and not (blue) in WT tumor. • Select 389 genes (marked in green in the heat maps) • Use k-means clustering to identify profiles of interest (eg differing between WT and KO tumor) -> three sets of genes (see cluster profiles)
Arrangement for k-means clustering WT KO T Uninv MCA T T Uninv MCA