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E. coli, H. pylori, P. aeruginosa , P. gingivalis , Staphylococcus spp.

Laboratory of Microbiology , Parasitology and Hygiene (LMPH) University of Antwerp Prof. dr. L. Maes - Prof. dr. P. Cos - Prof. dr. ir. P. Delputte louis.maes@ua.ac.be – paul.cos@ua.ac.be – peter.delputte@ua.ac.be. Bacteriology. Parasitology. Leishmania donovani , L. infantum

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E. coli, H. pylori, P. aeruginosa , P. gingivalis , Staphylococcus spp.

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  1. Laboratory of Microbiology, ParasitologyandHygiene (LMPH) University of Antwerp Prof. dr. L. Maes - Prof. dr. P. Cos - Prof. dr. ir. P. Delputte louis.maes@ua.ac.be – paul.cos@ua.ac.be – peter.delputte@ua.ac.be Bacteriology Parasitology • Leishmaniadonovani, L. infantum • Drug evaluation - In vitro & in vivo screening • Induction of experimental drug resistance • Characterization of paromomycin and • miltefosine resistance • E. coli, H. pylori, P. aeruginosa, P. gingivalis, Staphylococcus spp. • Development of in vitro and in vivo models • Development of multi-species biofilm models • Evaluation of anti-biofilm and anti-virulence • compounds • Quantification of micro-organisms by qPCR and FCM Mycology Virology • A. fumigatus, C. albicans, M. canis, T. rubrum • Implementation of a broth-microdilution method for in vitro antifungal susceptibility testing • Development of animal models • Respiratory Syncytial Virus (RSV) • Role of glycosylation in RSV pathogenesis • Interaction of RSV with macrophages • Modulation of the immune system • RSV induced lung pathology • Animal model that resembles pathology in young children Drug evaluation • Antimicrobial drug discovery: antibacterial, antifungal and antiparasitic evaluation • Focus on fungi and tropical protozoa (leishmaniasis, malaria, sleeping sickness and Chagas disease) • Multidisciplinary consortium for the identification and pharmacokinetic evaluation of new synthetic and natural lead compounds • DNDi reference screening and drug evaluation center Pathogen-macrophage interactions • Macrophage modulation via receptor signaling • Sialoadhesin (Sn; CD169) is a macrophage-restricted receptor that activates intracellular signaling upon ligand binding • Pathogens can engage Sn to modulate or escape from macrophage immune effector functions Campus Drie Eiken building S, 7th floor www.ua.ac.be/lmph • Role of bacterial biofilms in evasion from the bactericidal effect of macrophages • Development macrophage-biofilm co-culture model • Development in vivo S. aureus biofilm model • Intracellular hiding of Leishmania in macrophages • Leishmania exhibitis a non-typical intracellular phenotype in macrophages upon pressure of anti-parasitic drugs Oxidative stress • Quantification of oxidative stress in infectious diseases: H. pylori, Leishmaniaspp., Aspergillusspp. • Oxidative stress in lung-ischemia-reperfusion injury (IRI): role of free radical formation by endothelial and inducible NOS uncoupling and effect of eNOS cofactors

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