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‘Nanotechnology will change the very foundations

‘Nanotechnology will change the very foundations of cancer diagnosis, treatment, and prevention.’ - the National Cancer Institute. Vanderbilt Institute for Nanoscale Science and Engineering. Vanderbilt Institute for Integrative Biosystems Research and Education.

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‘Nanotechnology will change the very foundations

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  1. ‘Nanotechnologywill change the very foundations of cancer diagnosis, treatment, and prevention.’ - the National Cancer Institute Presentation to Vanderbilt University Board of Trust, June 23, 2005

  2. Vanderbilt Institute for Nanoscale Science and Engineering Vanderbilt Institute for Integrative Biosystems Research and Education Vanderbilt is ideally positioned to respond! An NCI-designated comprehensive cancer center Presentation to Vanderbilt University Board of Trust, June 23, 2005

  3. The Tennessee Center for Cancer Nanotechnology Excellence (TNCCNE) NCI grant:“Nanotechnology Applications to Cancer Metastasis” Announced: Dec 14th, 2004 Submitted: March 24, 2005 584 pgs, 65 lbs requested $20M (total) Reviewed: July 19-22, 2005 4-5 centers to be awarded Dept of Defense Army Breast Cancer grant:“Multifunctional nanoparticles for the detection and eradication of breast cancer metastases” Due: July 26, 2005 Multiple collaborative grant applications planned Presentation to Vanderbilt University Board of Trust, June 23, 2005

  4. Nuclear Science & Technology Division NanoMed Technologies TNCCNE Presentation to Vanderbilt University Board of Trust, June 23, 2005

  5. Why does cancer metastasize…..and how do we stop it? 5-year survival rate (average of 18 cancers) The ability of cancer cells to spread to distant parts of the body makes cancer a life-threatening disease 77% 50 29% 0 Distant metastases Local Presentation to Vanderbilt University Board of Trust, June 23, 2005

  6. http://www.nanopicoftheday.org/2003Pics/QDRainbow.htm Antibody targeting tumor blood vessels Quantum Dot Nanoparticle Tumor blood vessels Project 1: Targeting brain metastases with nanoparticles Breast to brain metastases *Hallahan Oncology *Prokop Engineering Harth Chemistry Davidson Biology Presentation to Vanderbilt University Board of Trust, June 23, 2005

  7. Nanofibers deliver suicide gene to MISC cells without permanent damage - delivered to tumor blood vessels Project 2: Trojan Horse *Yang Biology *Wright Chemistry Lin Biology Carbone Oncology McKnight Engineering ORNL Myeloid Immune Suppressor Cells (MISCs) circulate and incorporate into newly forming tumor blood vessels Presentation to Vanderbilt University Board of Trust, June 23, 2005

  8. Project 6: Nanotechnologies for early cancer detection: assaying proteins in blood serum ORNL Thundat Engineering Q-Dot Treadway Chemistry VINSE Giorgio Engineering Haselton Engineering VICC Carbone Oncology Serum proteomics can predict lung cancer and lung cancer metastasis (Lung SPORE) Presentation to Vanderbilt University Board of Trust, June 23, 2005

  9. Nanotechnologies for early cancer detection: assaying proteins in blood serum Nanocantilevers detect multiple proteins simultaneously 488 nm laser Different colored Quantum dots detect different serum proteins Blood protein pattern predicts cancer metastasis Presentation to Vanderbilt University Board of Trust, June 23, 2005

  10. Tumor-specific protease On/Off switch -----PLA*LW--- prodrug Active drug Qdot MRI CT Beacon for imaging Target to tumor cells Indicator of cell death Sensitivity Specificity Side effects -----VLA*D--- Multifunctional nanoparticles Dendrimer scaffold Presentation to Vanderbilt University Board of Trust, June 23, 2005

  11. PROJECT 6 PROJECT 5 Invasion:motility Metastatic potential of primary tumor PROJECT 2 Interaction with blood components PROJECT 4 Micrometastases: proteolysis Establishment of micrometastases Angiogenic switch to macrometastases PROJECT 3 PROJECT 1 Presentation to Vanderbilt University Board of Trust, June 23, 2005

  12. Lung Breast Gastrointestinal SPOREs Specialized Programs in Research Excellence • Translational cancer research • Clinical research and basic research • in each project • Approx $15M each Synergies with other transdisciplinary programs Vanderbilt-Ingram Cancer Center • Cancer Center Support Grant (NCI) • Clinical, Basic, and Population-based research • Infrastructure support (core facilities, admin) • $ 25M total Presentation to Vanderbilt University Board of Trust, June 23, 2005

  13. “Multiscale mathematical modeling of cancer invasion” Synergies with other transdisciplinary programs • P50 grant funded through NCI’s Integrative Biology Program • $15M total • Vito Quaranta, PI Presentation to Vanderbilt University Board of Trust, June 23, 2005

  14. Cancer Biology, Vanderbilt Alissa Weaver cell motility machinery Lynn Matrisian proteinases Ambra Pozzi angiogenesis Ann Richmond chemotaxis Jin Chen oncogenes Carlos Arteaga proliferation Al Reynolds cell-cell adhesion Vito Quaranta matrix adhesion Chemical Engineering, Vanderbilt Oak Ridge National Laboratory Peter Cummings computational sciences 2 x x v t a t = + + 0 Biomathematics, DundeeAlexander Andersonmathematical modelingBiomathematics, VanderbiltEmmanuele DiBenedettoGlenn WebbPhil Crookehomogenization theory, trainingDaphne Manousakimechanochemical modelingBioengineering, VanderbiltJohn Wikswosingle-cell measuring devicesImaging Sciences, VanderbiltJohn GoreCalum Avisonmouse MRI, PET, CT, etc.Science Communication, VUKathy Conkwrightoutreach, training Malignant/Invasive Normal Benign • Research • Cancer biology • Mathematics • Engineering • Education • Undergraduate • Graduate • Post-graduate • Community Presentation to Vanderbilt University Board of Trust, June 23, 2005

  15. High Dead I II III IV Low Cells MDE Oxygen ECM Presentation to Vanderbilt University Board of Trust, June 23, 2005

  16. “Microdevices for quantifying cell chemotactic responses“ Synergies with other transdisciplinary programs Vanderbilt Institute for Integrative Biosystems Research and Education • Bioengineering Research Partnership grant proposal • John Wikswo & Ann Richmond, PI Presentation to Vanderbilt University Board of Trust, June 23, 2005

  17. John Wikswo Franz Baudenbacher Michael Miga William Hofmeister Mark Stremler Todd Giorgio Prasad Shastri Ann Richmond Charles Lin Lynn Matrisian Alissa Weaver Dennis Hallahan Bonnie LaFleur Lisa McCawley Vito Quaranta Other • Mitchel Doktycz, Mike Simpson, ORNL • M. Martins-Greene, UC Riverside • Kevin Parker, Harvard • David Cliffel, Chemistry VU • Ricardo Richardson, Meharry Medical College Microdevices for quantifying cell chemotactic responses Presentation to Vanderbilt University Board of Trust, June 23, 2005

  18. Dynamic microfluidic gradient mixers • Identify chemotactic signaling processes Presentation to Vanderbilt University Board of Trust, June 23, 2005

  19. TNCCNE investigators have a history of collaborative interactions Publication or Presentation Grant Application Other Presentation to Vanderbilt University Board of Trust, June 23, 2005

  20. Educational opportunities • Cross-disciplinary research opportunities for graduate students and postdoctoral fellows • Cancer Biology Graduate Program (4 NCI training grants) • Multidisciplinary training in biomedical imaging program (NIH training grant supported, R. Price & L. Matrisian, PI) • Summer workshop for cross-training of mathematics and cancer biology (P50 supported) Presentation to Vanderbilt University Board of Trust, June 23, 2005

  21. Vanderbilt is ideally positioned to make a difference! Presentation to Vanderbilt University Board of Trust, June 23, 2005

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