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Session 7 “Radiotherapy – Quality of Life”

Session 7 “Radiotherapy – Quality of Life”. Moderation P.J.Bradley, MBA., FRCS. Nottingham Statement on Head and Neck Cancer Friday 27 th January, 2006. Strategies for Protecting Normal Tissue. Normal tissue tolerance limits Therapeutic Ratio = (TCP) Tumour Control Probability

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Session 7 “Radiotherapy – Quality of Life”

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  1. Session 7“Radiotherapy – Quality of Life” Moderation P.J.Bradley, MBA., FRCS. Nottingham Statement on Head and Neck Cancer Friday 27th January, 2006.

  2. Strategies for Protecting Normal Tissue Normal tissue tolerance limits Therapeutic Ratio = (TCP) Tumour Control Probability (NTCP) Normal Tissue Complication Probability

  3. Strategies for Protecting Normal Tissue

  4. Strategies for Protecting Normal Tissue Ideally, normal tissue protection strategies would move the NTCP curve to the right without compromise the TCP Ideally, therapeutic intensification strategies would move the TCP curve to the left without worsening NCTP

  5. Strategies for Protecting Normal Tissue Normal tissue-protection strategies Physical manipulation of the beam Alteration of the fractionation schedule Pharmacologic manipulation

  6. Strategies for Protecting Normal Tissue Morbidity Acute morbidity from radiotherapy is a function of the total dose delivered in a given period Late or chronic morbidity is dependent on the total dose delivered, and the size of the dose delivered.

  7. Strategies for Protecting Normal Tissue Quality of Life QLQ – C30 – Broad coverage of HnN QLQ – H&N35 – Specific measures, swallowing, saliva, Do we need a more specific CheoRT QLQ

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