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M261, Lecture 3 VDJ Recombination, Ig Class Switching, and Somatic Hypermutation April 8, 2005

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M261, Lecture 3 VDJ Recombination, Ig Class Switching, and Somatic Hypermutation April 8, 2005

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    6. V-regions are constructed from gene segments

    7. Organization of Ig and TCR Gene Loci

    8. Conserved Nonamer-Heptamer and 12/23 bp Spacer Rule

    9. Gene Rearrangement Can Occur by Deletion or Inversion of Intervening DNA, Depending on the Orientation of Gene Segments

    14. Ig Isotypes (Classes)

    15. Class Switch Recombination via Looping

    16. Degree of Variability at Each Position of the Variable Domain within a Mature Antibody Repertoire

    18. Mechanisms of Variable Domain Diversity

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