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Discover the latest research on how to reverse age-related brain atrophy and improve memory through a brain fitness program. Learn about the causes of memory lapses and how to prevent conditions like Alzheimer's. Find out how diet, fitness, and relaxation techniques can help grow your brain and reduce the risk of dementia.
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Grow Your Brain at Any AgeMajid Fotuhi, MD PhD Howard County Office on Aging Columbia, MD March 28, 2014
“This book may be the most important you’ll ever read. Certainly, what Dr. Fotuhi teaches in this book has changed mylife.” MichaelRoizen, M.D. Chairman of the Wellness Institute- The Cleveland Clinic
“Dr. Fotuhi has summarized the latest discoveries that show how we can grow our brains bigger and stronger…” Mehmet Oz, M.D. The Dr. Oz Show
Objectives • What happens to our brain with aging? • How to reverse age-related brain atrophy? • Brain Fitness Program
Memory lapses or Alzheimer’s? Memory Lapses Age-Associated Memory Impairment MCI Alzheimer’s
Cortex Hippocampus Short-term: HippocampusLong-term: Cortex
With Aging, Hippocampus Atrophies Fasterthan the Rest of the Brain Hippocampus shrinks by about 0.5% per year after age 50 That is the reason memory lapses become more frequent after age 50
Overlapping Causes of Atrophy in Hippocampus Obesity Stroke Sleep Apnea Diabetes Hypertension Stress Concussion AD
Higher Risk of AD for Those with Midlife Hypertension plus High Cholesterol • Longitudinal Study (1972, 1977, 1982, 1998) • 1449 participants • 57 cases of dementia, 48 with AD • Mild hypertension: <140 • Severe hypertension: >160 • High cholesterol: >250 BMJ 2001; 322:1447–51 12
Less Brain Volume in Patients with Sleep Apnea Am J RespirCrit Care Med 2002; 166:1382–7
Vascular Risk Factors Shrink the Brain, Especially the Hippocampus Multiple Vascular Risk Factors No Vascular Risk Factors Hippocampus Hippocampus
Obesity Shrinks the Brain • Associated with reduced brain volume Ward, et al., 2005 • Slows cognitive function Debette, et al., 2011 • Brains of overweight and obese individuals appeared 8 and 16 years older, respectively Raji, et al., 2010 Brain Research Volume 1280, 14 July 2009, Pages 186–194
Control Stress Stress Shrinks Brain Cells in Hippocampus 16
Plaques: gum-like collection of a protein called Amyloid Tangles: abnormal aggregation of a protein called Tau Inflammation Alzheimer’s: Plaques and Tangles
Hypertension Diabetes Alcoholism Depression Heart failure Obesity High cholesterol Head trauma Aging Poor sleep Too much work Information overload Too many responsibilities Fatigue Poor attention Poor diet “Can’t do it” mentality Why do we forget names?
Brain-healthy Diet Physical Fitness Cognitive Stimulation Meditation Diabetes Hypertension Obesity Sleep Apnea Head Trauma Genes Stress
Objectives • What happens to our brain with aging? • How to reverse age-related brain atrophy? • Brain Fitness Program
6 Steps to Grow Your Brain 1. Get Fit 2. Tease Your Memory 3. Eat Well &Take DHA 4. Sleep 5. Relax Your Mind 6. Start Early
1. Hippocampus Grows Biggerwith Getting Fit Erikson, PNAS 2011
Brain is a Highly Vascular Organ Zlokovic et al. Neurosurgery 43(4), 877–78, 1998
Hippocampus Grows Biggerwith Exercise, Even After 3 Months Before After Arch Gen Psychiatry, 2010
2. Hippocampus Grows Bigger with Memorization Training Draganski et al. J Neurosci 2006; 26:6314–7
4. Hippocampus Grows Biggerwith Treatment of Sleep Apnea Canesa, American Journal of Respiratory Medicine, 2011
5. Hippocampus Grows Bigger with Relaxing Your Mind Holzel , Psychiatric Research, 2011
Objectives • What happens to our brain with aging? • How to reverse age-related brain atrophy? • Brain Fitness Program
Brain Fitness Program A multidisciplinary program devoted to: Improving memory and brain performance Enhancing long-term brain health Reducing risk for dementia, Alzheimer’s disease and stroke in the future Each patient receives a comprehensive baseline assessment followed by a personalized treatment plan This program is based on latest research and has shown remarkable results
NeurExpand’s Unique Integrative Approach Customized Treatment Program to Maximize Brain Performance Comprehensive Diagnostics to Evaluate Brain Health
Remarkable Results Before HC Hippocampus After
Diabetes Hypertension Obesity Sleep Apnea Head Trauma Genes Stress Brain-healthy Diet Physical Fitness Cognitive Stimulation Meditation