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High Rates of Vitamin D deficiency among HIV-infected and At-risk Women in the United States

High Rates of Vitamin D deficiency among HIV-infected and At-risk Women in the United States.

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High Rates of Vitamin D deficiency among HIV-infected and At-risk Women in the United States

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  1. High Rates of Vitamin D deficiency among HIV-infected and At-risk Women in the United States Oluwatoyin M Adeyemi, Denis Agniel, Audrey L French, Phyllis Tien, Kathleen Weber, Marshall J Glesby, Maria C Villacres, Anjali Sharma, Daniel Merenstein, Elizabeth T Golub, William Meyer and Mardge Cohen for the WIHS group. WEPDB101

  2. Background and Methods • Vitamin D plays an important role in overall health. • Study to determine the prevalence and predictors of vitamin D deficiency among HIV-infected and uninfected women enrolled in the Women’s Interagency HIV study (WIHS). • Cross-sectional study of 1760 WIHS participants (1254 HIV-infected and 506 HIV-uninfected) who had stored sera collected from visit 27 (October 1, 2007-March 30, 2008). • Vitamin D testing was performed by Quest Diagnostics on frozen sera stored at -70°C using the liquid chromatography/mass spectroscopy(LC-MS) method. • Vitamin D deficiency was defined as 25 (OH) D <20 ng/ml; severe deficiency <10ng/ml. (To convert to nmol/L multiply by 2.496)

  3. Results • Median age 44 yrs, 61% African American, 22% White, 14% Hispanic. • For HIV+ women, median CD4 495 (295,662) • 66% of all women had Vitamin D Deficiency ; 22% severe deficiency (<10ng/ml) • 62% of HIV+ vs 75% of HIV- women were vitamin D deficient (p<0.001). • Median vitamin D levels were higher in HIV-infected (16, IQR 10-25) than HIV-uninfected women (14, IQR 9-20). • Only 13% had sufficient Vitamin D levels (>30ng/ml).

  4. Factors associated with Vitamin D Deficiency among 1760 WIHS women [1] For 10-unit increase 2 Estimated with restricted cubic spline function of CD4 Count, using midpoint of range

  5. Conclusions • High prevalence of Vitamin D deficiency in the WIHS- (largest study to date on vitamin D in HIV infected adults). • African American women had the highest rates of Vitamin D deficiency. • HIV infection was associated with lower rates of vitamin D deficiency. • In HIV+ women, Efavirenz use was associated with lower Vitamin D levels. • Important to explore response to vitamin D supplementation and impact on a myriad of health outcomes.

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