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SIRS MODS

Inflammation. Inflammation is immediate response to cellular injuryTriggered response to variety of causesIschemia, infection, trauma, foreign substances, malignanciesLimited to specific area ? localized inflammationLarge number or persistent inflammatory mediators released ? generalized

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SIRS MODS

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    1. SIRS & MODS Cindy Fehr Malaspina University-College BSN Nursing Program Nursing 335 Fall 2005

    2. Inflammation Inflammation is immediate response to cellular injury Triggered response to variety of causes Ischemia, infection, trauma, foreign substances, malignancies Limited to specific area ? localized inflammation Large number or persistent inflammatory mediators released ? generalized & systemic inflammatory response ? SIRS

    3. SIRS Systemic Inflammatory Response Syndrome Common causes Massive trauma, burns, pancreatitis, septic shock Characterized by presence of any 2 of the following clinical findings in response to tissue injury Temp > 38C or < 36C HR > 90 RR > 20 or respiratory alkalosis WBC > 12,000 or < 4,000 cells/mm3 or > 10% immature WBCs (bands) Can lead to altered circulation & coagulation; edothelial dysfunction; impaired tissue perfusion

    4. SEPSIS Syndrome on continuum When pt has findings of SIRS, PLUS, they have an infection Also known as a widespread inflammatory response caused by infection

    5. SEPSIS cont. Systemic Inflammation Characteristics Vasodilation of BV ? hypotension leaky capillaries ? ? bld circulating volume ? worsening hypotension ? metabolic rate ? microscopic clotting Persistence of these responses can lead to impaired blood flow to organs ? organ dysfunction Clinical Signs & Symptoms Chills - hypotension ? skin perfusion - ? u/o Significant edema or + fluid balance ? cap refill or mottling Hyperglycemia in absence of diabetes Unexplained change in mental status

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