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Objectives. What is dysplasia, and where does it come from?Natural history of dysplasiaHow do we find it, and what do we do about it?Prevention of dysplasia. Dysplasia. DysplasiaUnequivocally neoplastic transformationDysplasia in IBDMay be flat, difficult to detect at early stageMay be visibl
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1. Nuts and Bolts of Dysplasia in IBD Tad Dryden, MD, MSPH
Associate Professor of Medicine
University of Louisville
2. Objectives What is dysplasia, and where does it come from?
Natural history of dysplasia
How do we find it, and what do we do about it?
Prevention of dysplasia
3. Dysplasia Dysplasia
Unequivocally neoplastic transformation
Dysplasia in IBD
May be flat, difficult to detect at early stage
May be visible on endoscopy (elevated)
Dysplasia in a non-IBD Polyp
Even in the absence of IBD, every adenoma is dysplastic in normal people
ALL ADENOMAS ARE DYSPLASTIC BY DEFINITION
4. Why Do We Care?
5. Cumulative Risk of CRC in UC0.5-1.0% per year after 10 years of disease