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American Academy of ozonoterapy. Annual Meeting 2014 Dallas March 26-29 2014. OZONE THERAPY AND MULTIPLE SCLEROSIS: WHY?.
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American Academy of ozonoterapy • Annual Meeting 2014 • Dallas March 26-29 2014
NIRS Test: After 1 hour from starting reinfusion O2Hb increase in the frontal lobes, despite the constancy of carotid flow: a clear sign of increased microvascular perfusion and increased reactivity of hemoglobin Levy Reinfusion
NIRS signal during therapy O2Hb and HHb Thear is an increase of cerebral oxygenation for a long period , maximum from 20 minutes to 1,5 h after re-infusione .
TCD signals during therapy That is small variation of hematic flow.
Specific study of MS Complete analysis in time-frequency of NIRS segnals among 4 MS R-R and 5 heathy patients. Variation quantifier in time and frequency of cytocrome-c-oxidase concentration. Analysis by Principal Component Analysis program
Changes of CYT-c-oxidase Bibliography • Less concentration of CYT-c among MS patients, caused by damages of mythocondrions • MS patients have cronich oxidative stress • Ozonotherapy has anti-oxidant effect antixidant enzymes increase • Ozonoterapy may reduce oxidaditve stress in MS OUR experiment results • Low CYT-c in MS • CYT-c increases after 20’ to 40’ of reifusion • Higher level of CYT-c is a diagnostic value between MS patiens and other patiens
EDSS variactions * 4,3 3,8 * P < 0,05
FREQUENCY OF RECIDIVATION/YEAR * * P < 0,05
SYMPTOMATOLOGY * * * * * * * P < 0,005
FOLLOW-UP 1)No patient got worse 2)All spinals reflex bladders patients got better or recovered
Thanks Dr. Vincenzo Simonettiv.simonetti@tiscali.it