410 likes | 626 Views
The Time Machine:. Transforming Molecular Signals. into Long-Lasting Synaptic Change. David Santucci Quantitative Biology Bootcamp 2009. Presynaptic Release. Long Term Potentiation. Difference in time scale > 6 orders of magnitude. Induction. Expression. Early. Late.
E N D
The Time Machine: Transforming Molecular Signals into Long-Lasting Synaptic Change David Santucci Quantitative Biology Bootcamp 2009
Presynaptic Release Long Term Potentiation Difference in time scale > 6 orders of magnitude
Induction Expression Early Late
Prot ProtK P P Prot Protein Kinases Catalyze the Phosphorylation of Proteins
P P CaMKII
Induction Expression Early Late
Induction Expression Early Late
LTP TAG Prot
QDOT AB AMPA Single-Particle Tracking of AMPA Receptor Diffusion
488 nm 507 nm 405 nm 555 nm 572 nm Bleached Dendra2 Super-Resolution Imaging Using FPALM
488 nm 507 nm 405 nm 555 nm 572 nm Super-Resolution Imaging Using FPALM
Thanks to QB Program Jané Kondev Jeff Gelles Trisha Murray John Lisman Sri Raghavachari All of you...