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Multimodal Imaging in Clinical Neuroscience: Simultaneous MR – PET – EEG. Irene Neuner , Tracy Warbrick, Jörg Mauler, Joachim B. Kaffanke, Elena Rota Kops, Christoph Weirich, Frank Boers, Jürgen Scheins, Karl-Josef Langen, Hans Herzog and N. Jon Shah. Social Dimension. Lesch 2005, Kawohl 2012.
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Multimodal Imaging in Clinical Neuroscience:Simultaneous MR – PET – EEG Irene Neuner, Tracy Warbrick, Jörg Mauler, Joachim B. Kaffanke, Elena Rota Kops, Christoph Weirich, Frank Boers, Jürgen Scheins, Karl-Josef Langen, Hans Herzog and N. Jon Shah
Social Dimension Lesch 2005, Kawohl 2012
High Very Good Good Low Very Low Current MRI Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity
High Very Good Good Low Very Low Current PET Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity
High Very Good Good Low Very Low Hybrid MR-PET Anatomy Molecular Imaging Function Sensitivity/Specificity Temporal Clinical Utility Spatial Clinical Availability Development Prospects Technological Maturity
Protocol example • LOCALIZER localizer 00:27 • ATTENUATION / CSI planning mprage_1x1x1sag_pat2_bw610 04:40 • ATTENUATION UTE_417_32K_192_15 06:40 • ANATOM. DIAGNOSTIC t2_tirm_tra_dark-fluid 04:27 • fMRI ep2d_bold_restingstate 06:06 • DTI ep2d_diff_std 09:55 • SPECTROSCOPY csi_se_30 08:10 • PERFUSION ep2d_fid_perfusion 02:04 • ANATOM. DIAGNOSTIC mprage_1x1x1_sag_pat2_KM 05:14 • 47:43 PET listmode acquisition . MRI acquisition t t + 50 t t + 50 PERF CA CSI MPRAGE DTI FLAIR fMRI UTE localizer 5 8 10 2 5 6 6 4 2
3T Hybrid MR-PET: fMRI & DTI & PET Neuner et al. In press
Startle Reflex and fMRI T-values,FWE corrected, p<0,05, n=15 Neuner et al. 2010 1 sec
EEG at static 9.4T field Same subject, same stimuli, recorded under 9.4T Picked using Independent Component Analysis Auditory stimuli, recorded @ magnetic earth field in a mock scanner
EEG data acquired in the 3T MR and 3T Hybrid MR-PET system • Visual ERPS measured in response to a black and white checkerboard stimulus (200 trials). • Sensory and attention related ERP components identified. • All ERPs shown at occipital electrodes (O1 and O2). • Plots are shown with negative polarity up. • 32 Channel MR-compatible EEG system (Brainproducts, Germany) with MR-compatible cap. • Correction of the gradient artifacts (Allen et al. 2003) and cardiballistic artifact (Brainvision Analyzer 2.0., EEGlab).
3T MR P1 P2
3T Hybrid MR-PET P1 P2
3T MR and 3T Hybrid MR-PET Black – Trio Red – MR-PET
EEG Summary • Factors remaining the same across recordings: • Amplifier • Cap • Subject • Paradigms • Factors differing across recordings: • Screen • Distance from screen • Coil • Amplifier position • Subject position • Possible things to test to improve data quality: • ICA for correction • Amplifier position in MR-PET • Cable position and securing • Electronics of MR-PET
Thank you very much for your attention! • Jorge Arrubla • Frank Boers • Avdo Celik • Jörg Felder • Christian Filss • Hans Herzog • Karl-Josef Langen • Jörg Mauler • Jürgen Scheins • N.J. Shah • Gabriele Stoffels • Lutz Tellmann • Markus Ullisch • Tracy Warbrick • Christoph Weirich Black – Trio Red – MR-PET