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The role of kinin receptors (B1R and B2R) in the repair of skeletal muscle.

Department of Biochemistry and Molecular Biology Molecular Biology and Regenerative Medicine. The role of kinin receptors (B1R and B2R) in the repair of skeletal muscle. New therapeutic approaches to muscle injuries. Leonardo Martins, M.Sc. Advisor: João Bosco Pesquero , Ph.D.

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The role of kinin receptors (B1R and B2R) in the repair of skeletal muscle.

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  1. Department of Biochemistry and Molecular BiologyMolecular Biology and Regenerative Medicine • The role of kinin receptors (B1R and B2R) • in the repair of skeletal muscle. • Newtherapeutic approaches to muscle injuries Leonardo Martins, M.Sc. • Advisor: • João Bosco Pesquero, Ph.D 2019

  2. MusculoskeletalDisorders Are common and costly Affect all age groups Contribute significantly to disability, undermining the ability to work, overall quality of life and contributing to a loss of independence Are often paired with other conditions and diseases (co-morbidities), affecting health overall Warrant more research and practice investments, commensurate with their heavy toll on health, costs, and well-being Can be prevented and treated more effectively— often with knowledge and practices that already exist

  3. 1 in 8 persons of prime working age reported lost work days due to a musculoskeletal condition - a total of 216 million days - in 2016. Musculoskeletal diseases account for more than 50% of disabling health conditions reported by adults. Musculoskeletal diseases cost $796.3 billion dollars in 2012, 5.7% of the annual GDP Musculoskeletal diseases were diagnosed in 18% of the 1.3 billion health care visits in 2016. In any given year, 12% to 14% of the adult population will visit their physician for back pain. 54 of every 100 persons in the us, 126.6 million age 18 and over, reported suffering a musculoskeletal disease in 2012.

  4. Sports medicine Muscle injury is the most frequent event among athletes of various modalities, accounting for 55% of all cases and occurs in both recreational and competitive activities. Recent studies involving professional soccer athletes revealed that in over 500,000 hours of play there may be more than 4,500 injuries, 35.2% muscle injuries and an average of two injuries per season for each player. This situation leads to 27% of activity removals due to muscle injuries mainly in lower limbs and due to re-injury. (Schaseret al., 1999; Jarvinenet al., 2005; Ekstrandet al.,2011; Hägglundet al.,2013; Liu et al., 2012; Kristensonet al., 2013; Saw et al., 2017) In elite players, a prolonged period of inactivity during rehab is a significant economic problem for club owners. Currently, medicine has not only palliative care, but also apparatus and drugs for the complete recovery of the muscular injury, however it is known that most athletes withdraw from their activities for an average of six months, with about of 42% do not return to activities that need agility.

  5. MuscleInjuryTissueProgression Pre-injury Injured Healed The 3 most important processes: Angiogenesis Fibrogenesis Myogenesis Scartissue Healthytissue Strainedtissue SCAR TISSUE RISK OF RE-INJURY RANGE OF MOTION and Phases of skeletal muscle healing Inflammation Injury/ Degeneration Regeneration Fibrosis (post-injuryweeks)

  6. Thekallikrein-kinin system (KKS) components KKS mediators induce… ● vasodilation ● prostaglandin biosynthesis ● tissue remodeling through regulation of proteases ● pathophysiologies. KKS plays a role in… ● inflammation ● coagulation ● sodium homeostasis ● sensations of pain ● control of blood pressure

  7. Aimsofthestudy What is the role ofkininreceptors (B1R and B2R) in therepairofskeletalmuscle? Whatkindofinteractioneachofthesereceptors havewithangiogenic, myogenic andfibrogenic processes? Is modulation or control of these receptors relevant for the development of new therapies for regenerative medicine and rehabilitation medicine?

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