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GSI (MRK-003) SCRB siRNA

120. 110. 100. 54.8%. 100%. 54.8%. 100.0%. 90. 80. 70. 60. 50. 60.9%. 20.2%. 40. 30. p<.05. 20. *. % of Colonies per 12 High Powered Fields. 10. p<.01. **. 0. + – – –. DMSO/SCRB siRNA. – + – –. DMSO/PEA3 siRNA. – – + –.

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GSI (MRK-003) SCRB siRNA

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  1. 120 110 100 54.8% 100% 54.8% 100.0% 90 80 70 60 50 60.9% 20.2% 40 30 p<.05 20 * % of Colonies per 12 High Powered Fields 10 p<.01 ** 0 + – – – DMSO/SCRB siRNA – + – – DMSO/PEA3 siRNA – – + – GSI/ SCRB siRNA – – – + GSI/ PEA3 siRNA A. C. DMSO/PEA3 siRNA DMSO/SCRB siRNA MDA-MB-231 XENOGRAFTS 3.0 Vehicle + Controli 2.5 Vehicle + PEA3i MRK-003 GSI + Controli 2.0 PEA3i + MRK-003 GSI Cross Sectional Area (cm2) 1.5 1.0 ** p=.031 0.5 * p=.016 0.0 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 GSI (MRK-003) SCRB siRNA GSI (MRK-003) PEA3 siRNA Weeks D. B. 1.2 1.0 0.8 Relative PEA3 Transcripts 0.6 0.4 0.2 0.0 Controli PEA3i

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