TIMI 10A
TIMI 10A. Protocol Design. Pt. with Acute MI < 12h. TNK- tPA Bolus. 8 Ascending. TNK-tPA Doses:. 5, 7.5, 10, 15, 20,. 30, 40, 50 mg. ASA + IV Heparin (APTT 55-85). End Points:. Pharmacokinetics. Coagulation parameters. TIMI grade 3 flow at 90'. TIMI frame count. Major hemorrhage.
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