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Pathology of skin diseases ((Dermathopathology)). by S.S EGHBALI MD APCP. Macroscopic Terms. Macule Pustule Papule Wheal Nodule Scale Plaque Lichenification Vesicle Excoriation Bullae Onicholysis. Microscopic terms. Hyperkeratosis lentiginous
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Pathology of skin diseases((Dermathopathology)) by S.S EGHBALI MD APCP
Macroscopic Terms • Macule Pustule • Papule Wheal • Nodule Scale • Plaque Lichenification • Vesicle Excoriation • Bullae Onicholysis
Microscopic terms • Hyperkeratosis lentiginous • Parakeratosis Spongiosis • Acanthosis Exocytosis • Dyskeratosis Erosion • Acantholysis Ulceration • Papillomatosis Vacuolization
Urticaria (Hives) • Localized mast cell degranulation • Pruritic papules & plaques • Inflammatory cell infiltration • Edema • Dilated Vessles
Acute eczematous dermatitis • Papulo vesicular & oozing & crusted lesions • Drying , Acanthosis & Hyperkeratosis • Spongiosis • Lymphocytic infiltration • Varrious types by origin
Erythema multiforme • Drugs • Infections • Malignancies • C.V.D TCD 8 + (CTL) have important role
Erythema multiforme • Macule , Papule , Vesicle , Bullae • Target lesion is charactristics • Lymphocytic infiltration (CD4) • Keratinocyte necrosis • Epidermal necrosis
Psoriasis • Systemic disease • Scaly plaques • Erythroderma • Nail changes • Pustule formation • cont ….
Psoriasis • High epidermal turn over • Acanthosis • Elongation of rete ridges • Thining of granular laye • Cont…
Psoriasis • Auspitz ‘ s sign • Monro’s microabcess • Parakeratosis • Suprapapillary thining Activation of autoab.sandcomplement Haveimportant role in psoriasis
Lichen Planus • Pruritic & Polygonal papules • Wickham’s striae • Post inflammatory pigmentation • Mouth lesion cont ….
Lichen Planus • Band like infiltration • Basal cell degeneration • Saw-tooth appearance • Colloid (civatte) bodies • Hypergranulosis • Hyperkeratosis
Lapus erythematosus • SLE • DLE • SCLE Humoral & cellular lmmunity and complent haveimportant role in lupus
DLE • Malar rash • Discoid plaque • Scaling • Talengiectasia • Hypo & hyper pigmentation • cont ….
DLE • Lymphocytic infiltration • Basal cell degeneration • Epidermal atrophy • Follicular plagging • BM thickness (Pas +) • Lupus band test
Subcorneal bullae - Impetigo - Pemphigus folliaceus Suprabasal Bullae -Pemphigus Vulgaris Classification of bullousdis.
Sub epidermal bullae • Bullous pemphigoid • Dermatitis herpetiform • Epidermolysis bullosa • Purphyria
Pemphigus • Acantholysis • Inflammatory cell infiltration • Anti desmoglein – 3 • PA Serin protease • cont ….
Pemphigus Variants • P. Vulgaris (Supra basal) • P. Vegetans (Hyperkeratosis) • P. Folliaceus (granulosa) • P. Erythematosus (Malar)
Bullous Pemphigoid • Eldery Patient • Tense bullae without rupture • No sequelae • Subepidermal & nonacantholytic bullae • Lymph & PMN & EOS • Basal cell degeneration • cont ….
Bullous Pemphigoid • Anti lamina lucida • Anti hemidesmosomes • Activation of complement