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Stimuli-Responsive Polymer Nanofibers

Stimuli-Responsive Polymer Nanofibers. Y. Zhang, Prof. A. L. Yarin, Mechanical and Indutrial Engineering, UIC. Water insoluble novel NIPAM-based copolymers Swelling/shrinkage in response to temperature variation Swelling/shrinkage in response to pH variation Controlled drug release

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Stimuli-Responsive Polymer Nanofibers

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  1. Stimuli-Responsive Polymer Nanofibers Y. Zhang, Prof. A. L. Yarin, Mechanical and Indutrial Engineering, UIC • Water insoluble novel NIPAM-based copolymers • Swelling/shrinkage in response to temperature variation • Swelling/shrinkage in response to pH variation • Controlled drug release • Triggering at pH of 6.5 characteristic of cancer tumors • Water insoluble novel NIPAM-based, thermo- and pH-responsive copolymers were synthesized • These copolymers can distinguish between cancer tumors (pH 6.5) and normal tissues (pH 7.4) and release an anti-cancer drug in a highly localized manner, thus eliminating severe side effects • Future experiments should involve real anti-cancer drugs • Drug delivery with nanobots: carbon nanotubes containing anti-cancer drugs and capped with these stimuli-responsive copolymers • Co-polymerization of thermo-responsive NIPAM-PMMA copolymers • Co-polymerization of pH-responsive NIPAM-PMMA-AA copolymers • Electrospinning of nanofiber mats loaded with a model compound-fluorescent dye • Thermo- and pH-activated periodic dye release • To appear in: Y. Zhang, A. L. Yarin, J. Materials Chemistry (2010)

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