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Allows a new type of organ transplantation Living organ transplant Maintains organs in warn functioning state outside of

Allows a new type of organ transplantation Living organ transplant Maintains organs in warn functioning state outside of the body Hearts beat Lungs breath Kidneys produce urine Livers produce bile . Simulates conditions of the human body and allows the organ to function as it normally would

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Allows a new type of organ transplantation Living organ transplant Maintains organs in warn functioning state outside of

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  1. Allows a new type of organ transplantation • Living organ transplant • Maintains organs in warn functioning state outside of the body • Hearts beat • Lungs breath • Kidneys produce urine • Livers produce bile

  2. Simulates conditions of the human body and allows the organ to function as it normally would • Donor blood • Warms the organ as needed • Protects against contamination

  3. House all elements of the system • Oxygen supply • pump • Battery (transportation) • Digital screen for monitoring • Aortic pressure • Heart rate

  4. Sterile chamber • Protects the heart • Maintain temperature and humidity • Enables sterile ultrasound and blood sampling

  5. Provides nutrients to the organ they would normally receive in the body • Keeps the organ healthy during transplant

  6. Ischemic organs are cooled below normal temperature with fluids and ice to minimize cell death • The more times that passes the more damage • After certain time the organ becomes unusable • Most hearts transplanted in four hours • Many organs go unused because of this • Because organs are transplanted non-functioning underlying diseases or damage due to transplantation can not be detected

  7. Around 2,000 people receive heart transplants every year • 400 will die while waiting for a transplant • Donor hearts can last roughly four hours before they become unusable

  8. Two catheters are inserted into the heart • Aorta (blood enters) • Pulmonary artery • Aorta is attached to inflow • Inferior and superior vena cava, all other veins and arteries are all stitched closed so all the blood leaves through the pulmonary artery

  9. Blood leaves through the pulmonary artery • Passes through the oxygenator • Pumped through the heating element • Enters the heart through the aorta

  10. Increase the amount of time the organ can maintain outside of the body • Provides surgeons the opportunity to assess the organ outside of the body • Improve function of the organ after removal

  11. Typically, 92 to 95 percent of heart transplant patients are alive and their new heart is working after 30 days • Clinical trials in Europe, which concluded four years ago, showed 30-day survival rates for patients who received beating heart transplants were almost 98 percent.

  12. Primary outcomes • Increase 30 day survival rate of heart transplant patients • Secondary outcomes • Decreased ICU stay • Heart related adverse events • Rejection • Heart defects

  13. "Enabling the Functional Assessment of Organs for the First Time outside of the Body." How It Works: TransMedics, Inc. N.p., 2012. Web. 15 Oct. 2012. <http://www.transmedics.com/wt/page/how_works>. • "Frequently Asked Questions: TransMedics, Inc." Frequently Asked Questions: TransMedics, Inc. N.p., 2012. Web. 16 Oct. 2012. <http://www.transmedics.com/wt/page/faq>. • Kowalczyk, Liz. "Metro." BostonGlobe.com. N.p., 11 Jan. 2012. Web. 16 Oct. 2012. <http://bostonglobe.com/metro/2012/01/11/beating-heart-transplants-could-boost-success-rate/XG4Jzwy4ER9K1rIvGZfGyM/story.html>. • "Visual Dictionary Online." HUMAN BEING. N.p., 2012. Web. 18 Oct. 2012. <http://visual.merriam-webster.com/human-being/anatomy/blood-circulation/heart.php>. • "Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation (PROCEEDII)." Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation. N.p., 27 Sept. 2012. Web. 18 Oct. 2012. <http://clinicaltrials.gov/ct2/show/record/NCT00855712>. • Yeter, R., M. Hübler, M. Pasic, I. Grunwald, B. Youssef, M. Dandel, H. Lehmkuhl, R. Hetzer, and C. Knosalla. "Initial Single Center Experience with the Organ Care System for Heart Preservation." The Thoracic and Cardiovascular Surgeon 58.S 01 (2010): n. • Laliberte, Jennifer. "UK Surgeons Transplant Still-beating Heart." National Review of Medicine 3.12 (2006): n. pag. NRM: UK Surgeons Transplant Still-beating Heart. Web. 21 Oct. 2012. <http://www.nationalreviewofmedicine.com/issue/2006/06_30/3_advances_medicine02_12.html>.

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