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Planning a family

Training. Planning a family. What is a Food Supplement?. Contents. Key message Introduction Product i nformation Key b enefits Target group Posology & administration Ingredients Folic Acid Iodine Other micronutrients 11. Complementary treatment 12. References.

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Planning a family

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  1. Training Planning a family

  2. What is a Food Supplement?

  3. Contents Key message Introduction Product information Key benefits Target group Posology & administration Ingredients Folic Acid Iodine Other micronutrients 11. Complementary treatment 12. References

  4. 1. Key message • A pregnancy is one of the most fascinating things that a woman will ever experience. • The 40 weeks of pregnancy leading up to the baby’s birth are full of fascinating milestones and physical transformations of both mother and child. • To support a healthy development of the unborn child in the womb it is important that the mother-to-be is sufficiently supplied with all important nutrients. provides all important nutrients for women planning a pregnancy and for women during the first 12 weeks of pregnancy - for a healthy development of the unborn child.

  5. 2. Introduction • A pregnancy is divided into three stages, called trimesters.first trimester, second trimester and third trimester. • During each trimester, different changes take place in a pregnant woman’s body as well as in the developing fetus. 4 1 2 3 5 6 7 8 9 Month 1. Trimester 2. Trimester 3. Trimester

  6. 2. Introduction • Weeks 1 & 2: Getting ready! • Week 3: Fertilization • Week 4: Implantation • Week 5: Hormone levels increase • Week 6: The neural tube closes • Week 7: Baby’s head develops • Week 8: Baby’s nose forms • Week 9: Baby’s toes appear • Week 10: Baby’s elbows bend • Week 11: Baby’s genitals develop • Week 12: Baby’s fingernails form 1. Trimester 1 1 2 3 Month

  7. 2. Introduction • Week 13: Urine forms • Week 14: Baby’s sex becoming apparent • Week 15: Baby’s scalp pattern develops • Week 16: Baby’s eyes move • Week 17:Baby’s toenails develop • Week 18: Baby begins to hear • Week 19: Baby develops protective coating • Week 20: The halfway point • Week 21: Baby can suck his or her thumb • Week 22: Baby’s hair becomes visible • Week 23: Fingerprints and footprints form • Week 24: Baby’s skin is wrinkled • Week 25: Baby responds to your voice • Week 26: Baby’s lungs develop • Week 27: 2nd trimester ends 2. Trimester2 4 5 6 Month

  8. 2. Introduction • Week 28: Baby’s eyes partially open • Week 29: Baby kicks and stretches • Week 30: Baby’s hair grows • Week 31: Baby’s rapid weight gain begins • Week 32:Baby practices breathing • Week 33: Baby detects light • Week 34: Baby’s fingernails grow • Week 35: Baby’s skin is pink and smooth • Week 36: Baby takes up most of the amniotic sac • Week 37: Baby might turn head first • Week 38: Baby’s toenails grow • Week 39: Baby’s chest is prominent • Week 40: The due date arrives! 3. Trimester 3 7 8 9 Month

  9. 3. Product information Beforepregnancyandduring the firsttrimester

  10. 3. Product information Beforepregnancyandduring the firsttrimester

  11. 4. Key benefits • Very good compliance - only 1 tablet per day • One tablet a day covers the recommended daily intake of folic acid and • other micronutrients that are essential for the development of a healthy • child 4, 5 • Ensures adequate folate levels at time of conception 6, 7 • Fast folate status recovery for women who were not able to supplement folic acid 3 months prior conception 7, 8 • Higher bioavailability of folic acid contained in prenatal Denk than folate that occurs naturally in food 9

  12. 5. Target group • prenatal D provides all important vitamins, folic acid and iodine for women during the first 12 weeks of pregnancy. • The intake of is also recommended for women planning a pregnancy because folate levels should already be adequate at the time of conception.

  13. 6. Posology & administration • INTAKE • The recommended intake is 1 tablet per day taken with a meal • and plenty of liquid. • STARTING DATE • For women before and during the first 12 weeks of pregnancy • Taking folic acid before getting pregnant is essential to support a healthy development of the unborn child (e.g. neural tube) • Neural tube formation is already complete 28 days after conception (which is round about pregnancy week 6) 1( often before women even now they are pregnant) Recommendations START AS SOON AS POSSIBLE

  14. 7. Ingredients • Facilitates the sufficient supply of certain micronutritions that are essential for the development of a healthy child • Ensures adequate folate levels at time of conception • Only 1 coated tablet per day covers the recommended daily requirement of folic acid, iodine and of numerous essential vitamins

  15. 8. Folic acid Globally, it is estimated that approximately 300,000 babies are born each year with neural tube defects. 10, 11About half of these cases are thought to be related to inadequate folic acid intake by the mother. 11 • Neural tube defects are common birth defects which include: • 1) SPINA BIFIDA 12, 13, 14 • The vertebrae surrounding the spinal cord does not close properly during the first 28 days after fertilization => Spinal cord is exposed • A majority of babies born with this condition grows to • adulthood with various degrees of disability (paralysis, inability to control bowel and bladder • function). • 2) ANENCEPHALY 14 • Anencephaly is a condition in which most or all of the brain is absent. • Infants with this condition die shortly after birth

  16. 8. Folic acid Essential role of folic acid in other physiological functions 5 • DNA synthesis, DNA repair, DNA methylation • Co-factor in biological reactions • Cell division and growth • Production of red blood cells  Prevention of anaemia • Essential for brain functions (mental and emotional health) Other risks linked to folic acid deficiency 15, 16 • Higher risks of heart attacks and stroke • Higher risk of some cancers (e.g. stomach cancer) • Cell division and growth • Considerable decrease in male sperm count and fertility • Higher risk of developing clinical depression

  17. 8. Folic acid • Humans cannot synthesize folate “de novo” 16 • Special foods help obtain the recommended amount of folic acid 16 • leafy, dark green vegetables • citrus fruits and juices, berries • legumes (dried beans and peas) • whole grains, breakfast cereals • rice, pasta Excessive cooking can remove or destroy folate contained in food (Folic acid is heat labile!) …

  18. 8. Folic acid • Synthetic folic acid is better absorbed folate from foods • (1 µg food folate = 0.5 µg supplement folic acid) 16 • Even if a women keeps to a well balanced diet, she may not get • the extra folic acid she needs to prevent birth defects 4, 7 800 µg folic acid Essential Vitamins A daily amount of at least 600 µg of folic acid, three months prior conception and during the first three months of pregnancy, is recommended. 7 +

  19. 8. Folic acid Intake recommendations: 17

  20. 8. Folic acid • prenatal Denk contains 800 µg of folic acid • The folate status increases faster with 800 µg/d compared to • 400 µg/d8 • Supplementation with 800 µg/d leads to erythrocyte folate • concentration above the neural tube defect cut-off (906 • nmol/L) after 4 weeks and only after 8-12 weeks with 400 • µg/d folic acid.6 Fast folate status recovery (due to high folate concentration) for women who were not able to supplement folic acid 3 months before conception.

  21. 9. Iodine • Iodine is essential to produce thyroid hormones which ensure normal development of the brain and nervoussystem before birth and in babies and young children • Iodine Deficiency During Pregnancy and Breastfeeding 18, 19 • Mental retardation (reduced IQ) of newborns • Cognitive delays in newborns • Increased infant mortality Role of Iodine 18 …

  22. 9. Iodine • Iodine during pregnancy 18 • During pregnancy, 50 % more thyroid hormones are produced. • Iodine in breastfeeding 18 • Production rate of thyroid hormone returns to normal when breastfeeding. • HOWEVER: Breast fed infants are completely dependent on milk as a source of iodine ( need around 90-100 µg /d ).

  23. 9. Iodine The National Health and Medical Research Council (NHMRC) recommends that all women who are pregnant, breastfeeding or considering pregnancy take an iodine supplement of 150 µg/d. 18 150 µg Iodine

  24. 10. Other micronutrients Contribution to maintaining a normal energy metabolism. 20 Vitamin B2 Pantothenic acid Vitamin B1 Biotin Niacin Vitamin B6 Reduction of tiredness und fatigue. 20 Vitamin B12 Protection from oxidative stress. 20 Vitamin E Support of the immune system and increase of iron resorption. 20 Vitamin C

  25. 11. Complementary treatment FOR FATHERS- TO-BE FOR MOTHERS-TO-BE may change your (family) life

  26. 12. Refereneces 1 Mayo Clinic (2018): Pregnancy week by week. Fetal development: The 1st trimester. https://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/prenatal-care/art-20045302 2 Mayo Clinic (2018): Pregnancy week by week. Fetal development: The 2nd trimester. https://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/fetal-development/art-20046151 3 Mayo Clinic (2018): Pregnancy week by week. Fetal development: The 3rd trimester. https://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/fetal-development/art-20045997 4Werler MM (1999): Achieving a public health recommendation for preventing neural tube defects with folic acid. Am J Public Health. 89 (11): 1637-1640. 5 Berg MJ (1999): The importance of folic acid. J GendSpecif Med. 2 (3): 24-28. 6 Lamers Y (2006): Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age. Am J ClinNutr. 84 (1): 156-161. 7 Lamers Y (2011) Folate recommendation for pregnancy, lactation, and infancy. Ann NutrMetab. 59: 32-37. 8 Brämswig S (2009): Supplementation with a multivitamin containing 800 µg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J VitamNutr Res 2009. 79 (2): 61-70. 9 Natural Medicines (2018): Folic acid. 10 Zaganjor I (2016): Describing the Prevalence of Neural Tube Defects Worldwide. PLOS one.

  27. 12. Refereneces 11 Christianson A (2006): March of dimes. Global report on birth defects. 12 Centers for Disease Control and Prevention (2017): Spina Bifida. Basics. https://www.cdc.gov/ncbddd/spinabifida/facts.html 13 Eunice Kennedy Shriver National Institute of Child Health and Human Development (2017): Neural Tube Defects: Condition Information. https://www.nichd.nih.gov/health/topics/ntds/conditioninfo/default 14 Mayo Clinic (2018): Spina bifida. https://www.mayoclinic.org/diseases-conditions/spina-bifida/symptoms-causes/syc-20377860 15 Nordqvist C (2017): What to know about folic acid. Med News Today. http://www.medicalnewstoday.com/articles/219853.php 16 National Institutes of Health (2018): Folate. Dietary Supplement fact Sheet. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/ 17 Institute of Medicine. Food and Nutrition Board (1998): Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington, DC, National Academy Press. 18 NHMRC Public Statement (2010): Iodine Supplementation for pregnant and breastfeeding women. 1-4. 19 National Institutes of Health (2018): Iodine. Fact Sheet for Health Professionals. 20 European Commission (2012): Commission Regulation (EU) 432/2012.

  28. Join Denk Pharma Our contributions to keeping you healthy: • Affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, packaging, studies, consultation, availability, support, etc… • Raise awareness by conducting Check Up Days (blood glucose, blood pressure, cholesterol and triglyceride) • Constantly enhancing the product portfolio

  29. HEALTHCARE MADE IN GERMANY since 1948

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