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Muscle Structure and Function. Biology 2121 Chapters 9-10. Introduction. 1. Functions Movement, Posture; Heat and Joints 2. Naming (321) Location; Shape ( temporalis ; deltoid) Size (gluteus maximus ) Fiber Direction ( abdominus rectus) Origins (bicep)
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Muscle Structure and Function Biology 2121 Chapters 9-10
Introduction 1. Functions • Movement, Posture; Heat and Joints 2. Naming (321) • Location; Shape (temporalis; deltoid) • Size (gluteus maximus) • Fiber Direction (abdominus rectus) • Origins (bicep) • Location of Attachment (sternocleidomastoid)
Major Muscle Groups Chest and Shoulder Group Abdominals Quadriceps and Hamstring Group
Histology of Muscle Tissue- Skeletal Muscle • Voluntary • Found in major muscle groups • Striated • Multinucleated • Peripheral
Smooth Muscle • Involuntary • Found in digestive system organs, bladder, etc. • Non-Striated • Uninucleated • Spindle-Shaped nuclei
Cardiac Muscle • Involuntary • Heart only • Branching Fibers • Uni-Nucleated
Gross Anatomy • 1. Wholemuscle • Epimysium • 2. Fascicles • Perimysium • 3. MuscleFiberCells • Long and multi-nucleated • Sarcolemma and sarcoplasma • Endomysium
Attachments • Tendons • Aponeurosis • Direct or Indirect Attachments
Microscopic Anatomy – Myofibrils • 1. Contractileproteins • 2. Sarcomeres • Actin and myosin • 3. Myofilaments • Actin(thin) • Myosin (thick)
Sarcomere • 1. A ‘sarcomere’ • Z to Z • I-Band (light zone) • A-Band (dark zone) • 2. StructuralProteins • Elastic filaments – Titan • 3. SlidingFilamentModelof Contraction • Link
Chemical Stimulation and Muscle Contractions • 1. Stimulation and Neurotransmitters • Acetylcholine • 2. NeuromuscularJunction • Junction – muscle/nerve interface • Separation – “synapse”
Events at the Neuromuscular Junction • 1. Nerve Impulse • 2. Calcium ions – Axon Terminal of Nerve • 3. Vesicle and release of ACh • 4. ACh receptors and Acetylcholinesterase • 5. Sodium-Potassium exchange • 6. Action Potential formed
Action Potential • 1. RestingMembrane • -70 mV • Na+ and K+ • 2. Reversalof Charges • Depolarization • 3. Movesin oneDirection
Excitation and Contraction • 1. ActionPotential moves along the sarcolemma • 2. Down the T-Tubule • 3. SarcoplasmicReticulum and Release of Ca++ • 4. Ca++ moves to the sarcomere
Formation of a Cross-Bridge • 1. Ca++ interacts with troponin • 2. Removestropomyosin • 3. Allows for MyosinHeadAttachment • 4. Formation of a cross-bridge
Cross-Bridge Cycling • 1. Myosinheadsattach forming cross- bridge • 2. WorkingStroke • 3. ATPbreaks cross- bridge • 4. ATPhydrolysis • 5. High-energy configuration – New Cross-bridge
ATP and Muscle Metabolism ATP Functions – Driving Cellular Work
ATP Production 1. CreatinePhosphate – Quick and Fast!!! 2. AnaerobicRespiration • “Lactic Acid Fermentation” • 1 glucose molecule = 2 ATP Net 3. AerobicRespiration • 1 glucose molecule = 36 ATP Net • Mitochondria of the Cell
Fermentation • Glycolysis • (2) Pyruvicacidmolecules (3-C) • Bloodflowrestrictedduring vigorous exercise (low oxygen) • Lacticacidformed • Anaerobic glycolysis