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0 nM CFMTI. 3 nM CFMTI. 10 nM CFMTI. 30 nM CFMTI. 125. 100. 75. Ca 2+ moblization (% of 1 mM L-Glu response). 50. 25. 0. -9. -8. -7. -6. -5. -4. -3. -2. Log [L-glutamate] (M).

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  1. 0 nM CFMTI 3 nM CFMTI 10 nM CFMTI 30 nM CFMTI 125 100 75 Ca2+moblization (% of 1 mM L-Glu response) 50 25 0 -9 -8 -7 -6 -5 -4 -3 -2 Log [L-glutamate] (M) Supplemental Figure 2. Effect of CFMTI on concentration-response curves for L-glutamate-induced increases in intracellular Ca2+ mobilization. Concentration response curves for L-glutamate in the absence or presence of CFMTI at 3 to 30 nM in CHO cells expressing human mGluR1a. Results are expressed as a percentage of the response to 1 mM L-glutamate, and they are mean  S.D. of the representative experiment in three independent experiments performed in triplicate. Ca2+ mobilization assay were carried out as described in Methods.

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