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Membrane Structure

Membrane Structure. Functions of Membranes Permeability barrier Compartmentalize the cell into organelles; organelles contain specific enzymes/ macromolecules Signal Transduction; receptor/ligand complex. Synthesis of membranes Plasma membrane ER Golgi Lysosomes/Endosomes

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Membrane Structure

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  1. Membrane Structure

  2. Functions of Membranes Permeability barrier Compartmentalize the cell into organelles; organelles contain specific enzymes/ macromolecules Signal Transduction; receptor/ligand complex

  3. Synthesis of membranes Plasma membrane ER Golgi Lysosomes/Endosomes Etc. Synthesis Post-translational of Lipids/ modification, Proteins processing, sorting

  4. Composition of Membranes Lipids 45-50% (mass) Proteins 45-50% Carbohydrates ~5%

  5. Types of lipids Phospholipids Sphingolipids Cholesterol

  6. Phospholipid GlycerolFatty acid H O | || H - C - OH + HO - C - CH2 - CH2 - CH2 ------ | H - C - OH + HO - C - CH2 - CH2 - CH2 ------ + - | || R + (P) +HO - C - H O | H R-group and phosphate group carry charge (hydrophilic)

  7. Phospholipid ester linkage GlycerolFatty acid (hydrophobic) H O | || H - C - O - C - CH2 - CH2 - CH2 ------ | H - C - O - C - CH2 - CH2 - CH2 ------ + - | || R + (P) - O - C - H O | H R-group and phosphate group carry charge (hydrophilic)

  8. R - groups Serine Ethanolamine Choline Inositol Phosphatidyl Serine PS Phosphatidyl Ehtanolamine PE Phosphatidyl Choline PC Phosphatidyl Inositol PI

  9. Phospholipids are amphipathic part hydrophilic part hydrophobic Simplified diagram

  10. Phosphatidyl Serine has net negative charge

  11. Sphingolipids

  12. Milestones in Membrane Biology 1. Gorter and Grendel Lipid bilayer 2. Daveson and Danielli Lipid bilayer coated with proteins 3. J. David Robertson Unit Membrane = 7 nm 4. Singer and Nicolson Fluid Mosaic Model

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