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The Endocrine System. The Endocrine System Functions. Primary function is to produce hormones Hormones chemical messengers which control body development, function, life. The Endocrine System Steroid Hormones. Control metabolism inflammation immune functions salt & water balance
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The Endocrine SystemFunctions • Primary function is to produce hormones • Hormones chemical messengers which control body development, function, life
The Endocrine SystemSteroid Hormones • Control • metabolism • inflammation • immune functions • salt & water balance • development of sexual characteristics • ability to withstand illness & injury
The Endocrine SystemAnabolic Steroids • Related to male testosterone • taken to build strength & muscles • Side effects • liver damage • altered body chemistry • testicular shrinkage • breast development • mood swings & violence • Stops long bone growth
The Endocrine SystemStructures • Pituitary Gland 1 • Thyroid 1 • Parathyroid 4 • Adrenal glands 2 • Pancreas 1 • Thymus 1 • Pineal gland 1 • Gonads 2
The Endocrine SystemMedical Specialties • Endocrinologist
The Endocrine SystemPathology • Endocrinopathy • Hypercrinism • Hypocrinism
The Endocrine SystemPituitary Gland-Anterior • Adrenocorticotropic Hormone ACTH (adreno- adrenal) (cortic/o = cortex)) (-tropic = stimulating) Adrenotropin • Stimulates adrenal cortex
The Endocrine SystemPituitary Gland-Anterior • Follicle-stimulating hormone FSH • Female • Stimulates secretion of estrogen • Growth of ova (eggs) in the ovaries • Male • Stimulates production of sperm
The Endocrine SystemPituitary Gland-Anterior • Growth hormone GH or somatropin STH (somato= body) • Regulates growth of muscles, bones, & other tissue
The Endocrine SystemPituitary Gland-Anterior • Lactogenic hormone LTH or prolactin • Stimulates & maintains secretion of breast mink after birth.
The Endocrine SystemPituitary Gland-Anterior • Luteinizing Hormone LH or Luteotropin • Female • Stimulates ovulation • Male • Stimulates testosterone secretion
The Endocrine SystemPituitary Gland-Anterior • Melanocyte-stimulating hormone MSH or melanotropin • Increases pigmentation
The Endocrine SystemPituitary Gland-Anterior • Thyroid-stimulating hormone TSH or thyrotropin (thyro- = thyroid) • Stimulates the growth and secretions of the thyroid gland
The Endocrine SystemPituitary Gland-posterior • Antidiuretic hormone ADH • Maintains water balance by reabsorption of water in the kidneys. >ADH=<urine • Diuretic > = > • Oxytocin OXT • Stimulates uterine contraction at birth • Stimulates flow of milk after birth
The Endocrine SystemPituitary Gland-pathology • Acromegaly • Alcohol consumption • Gigantism • Hyperpituitarism • Hypopituitarism • Pituitarism • Diabetes insipidus • Polydipsia • polyuria
The Endocrine SystemThyroid Gland • Lies on either side of the larynx • Regulates metabolism • Thyroxine (T4 ) • Triiodothyronine (T4) • Calcitonin or thyrocalcitonin • Regulates calcium
The Endocrine SystemThyroid Gland-Pathology • Hypothyroidism Underactive thyroid • Cretinism • Myxedema • Hyperthyroidism • Graves’ disease • Goiter • Exophthalmos
The Endocrine SystemThyroid Gland-diag. & treatment • Thyroid scan • Chemical thyroidectomy radioactive iodine therapy • TSH assay
The Endocrine SystemParathyroid Gland Parathyroid Hormone PTH or parathormone • Regulates calcium • Hypoparathyroidism = hypocalcimia • abn. Low calcium • Hyperparathyroidism = hypercalcimia • abn. high calcium • Tetany
The Endocrine SystemAdrenal Glands • Controls electrolyte function • Helps regulate metabolism • Adrenal Cortex • Adrenal Medulla
The Endocrine SystemAdrenal Cortex • Corticosteroid • Mineralocorticoids • Glucocorticoids • Gonadotropins
The Endocrine SystemAdrenal Medulla • Epinephrine
The Endocrine SystemAdrenal Glands- Pathology • Adrenalitis • Addison’s • Aldosteronism • Pheochromocytoma • Cushing’s syndrome • Laparoscopic adrenalectomy
The Endocrine SystemPancreatic Islets or Islets of Langerhans • Glucagon (alpha cells) • Insulin (beta cells) • Hyperglycemia • Hyperinsulinism • Hypoglycemia • Diabetes mellitis
The Endocrine SystemPancreatic Islets or Islets of LangerhansDiabetes Mellitus • Type 1 insulin-dependent diabetes mellitus • 0r juvenile diabetes • Due to destruction of beta cells • insulin • Type 2 non-insulin-dependent diabetes m. or adult onset diabetes • Diet, exercise & ornase
The Endocrine SystemPancreatic Islets or Islets of Langerhans • Diagnostics • Fasting blood sugar • Glucose tolerance test • Emergencies • Hypoglycemia low blood sugar =diabetic shock • Hyperglycemia high blood sugar • Diabetic ketoacidosis DKA = diabetic coma • Complications
The Endocrine SystemThymus • Thymus (thym/o) • Role in immune system • Thymosin
The Endocrine SystemPineal gland • Influences sleep-wake cycle • Melatonin • Pinealopathy • Pinealectomy
The Endocrine SystemGonads • Dev. & main. Secondary sex characteristics • Testicles - testosterone • Ovaries • Estrogen • Progesterone • Placenta • Human chorionic gonadotropin HCG