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BIOINFORMATICS

BIOINFORMATICS. Presentation by Kate Steidle December 2, 2003. Gene Identification. Diapause or Non-diapause?. Centrosomin. - Characteristics : Centrosomal protein; 150 kDa; found in Drosophila

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BIOINFORMATICS

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  1. BIOINFORMATICS Presentation by Kate Steidle December 2, 2003

  2. Gene Identification

  3. Diapause or Non-diapause?

  4. Centrosomin -Characteristics: Centrosomal protein; 150 kDa; found in Drosophila • Functions: Major centrosomal protein required for the assembly and function of the centrosome at mitosis • Biological Processes: central nervous system development; centrosome cycle; female meiosis chromosome segregation; midgut development; peripheral nervous system development • Cellular Components: Centrosome; myosin

  5. Amino Acid Sequence • >CG18370-MDQSKQVLRDYCGDGNGTCASSLKEITLIETVTSFLEENGAAEIDRRVLRKLAEALSKSIDDTSPGALQDVTMENSYASFDVPRPPGGGNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIATLRKTVDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTRKMLRLESEVQRLEEELVNIEARNVAARNELEFMLAERLESLTACEGKIQELAIKNSELVERLEKETASAESSNANRDLGAQLADKICELQEAQEKLKERERIHEQACRTIQKLMQKLSSQEKEIKKLNQENEQSANKENDCAKTVISPSSSGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNKELWEKNREVERLTKLLANQQKTLPQISEESAGEADLQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDVLGVLAADRRNAMRKAVDRSLDLSKSLNMTLNITATSLADQSLAQLCNLSEILYTEGDASHKTFNSHEELHAATSMAPTVENLKAENKALKKELEKRRSSEGQRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPEQAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDERMLNVQCQMVELDNRYKQEQLRCLDITQQLEQLRAINEALTADLHAIGSHEEERMVELQRQLELKNQQIDQLKLAHSTLTADSQITEMELQALQQQMQEIEQLHADSVETLQSQLQKLKLDAVQQLEEHERLHREALERDWVALTTYQEQAQQLLELQRSLDYHQENEKELKQTLVENELATRALKKQLDESTLQASKAVMERTKAYNDKLQLEKRSEELRLQLEALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRVNTSSPDLGIESDAGRISSVEVSNAQRAMLKTVEMKTEGSASPKAKSEESTSPDSKSNVATGAATVHDCAKVDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNMENEL

  6. Conserved Domains

  7. Clustalw • Drosophila - Fruitfly • Anopheles - Pest • Danio rerio – Zebrafish • Homo sapiens - Human

  8. CG18370 clustalw.doc

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