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HumMod – Golem Edition Human Physiology Model

HumMod – Golem Edition Human Physiology Model. J.Kofr ánek , M.Mateják , P.Privitzer , T.Kulhánek J.Šilar , F.Ježek , S.Matoušek. Histor y. 1972 – A.Guyton & col.: Overall circulation 1978 – N.Ikeda & col.: Body fluids from 1997 – J.Kofranek & col.:Physiolibrary

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HumMod – Golem Edition Human Physiology Model

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  1. HumMod – Golem Edition Human Physiology Model J.Kofránek, M.Mateják, P.Privitzer, T.Kulhánek J.Šilar, F.Ježek, S.Matoušek

  2. History • 1972 – A.Guyton & col.: Overall circulation • 1978 – N.Ikeda & col.: Body fluids • from 1997 – J.Kofranek & col.:Physiolibrary • 2005 – S.Andersen & col.: OSA • 2008 – T.Coleman& col.: QHP 2008 beta 2 • 2010 – T.Coleman & col. : HumMod Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  3. T.Coleman DS 2009

  4. 2833 files in 772 folders DS 2009

  5. HumMod GolemEdition • CardioVascular • Metabolism • Heat • Water • Proteins • Gases • Electrolytes • Nerves • Hormones • Status Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  6. Gases • Oxygen • Carbondioxyd • Titratable Hydrogen Ion • Respiratory Center Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  7. Oxygen • Concentration Conpartement • Tissues Oxygen • Blood O2 Diffusion • AlveolarVentilation • Breathing • Blood O2 Measurement Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  8. Titratable Hydrogen Ion • Concentration Conpartement • Tissues:H+ in blood, IST and ICF • Renal Acidification: H+ and NH4+ • Blood pH Measurement Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  9. Model Setup/Inputs • Initial state values (~150) • Masses, Volumes, .. • Steady State • Parameters and Constants (~4000) • Characterizations of Elementary things • Identification (Also Indirect Meassurement) • Simple Environment Model • Meat, Air, Exercise, Intravenous Nutritions, Transfusion, Dialysis, Hemorrhage, ... Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  10. HumMod.Library • Domains: • Hydraulic (mmHg, ml/min, ..) • Concentration (mol/ml, mol/min, ..) • Osmotic(mol/ml, ml/min, ..) • Termoenergetic (K, kCal/min, ..) • Simple blocks: • Resistance, Accumulation, Pump, Outflow, Absorbtion, Chemical reaction .. Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching

  11. HumMod Golem Edition

  12. Thank you for attention Marek Mateják marek.matejak@lf1.cuni.cz Jiří Kofránek kofranek@cesnet.cz Pavol Privitzer

  13. HumMod Golem Edition

  14. HumMod Golem Edition

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