Penises and Pathology

1. Penises and Pathology

3. Normal prostate and bladder

5. Prostatic abscess, best seen on the inferior aspect of the specimen, in a man aged 72 with diabetes mellitus complicating haemochromatosis. The contents of the abscess have been removed to display the pyogenic membrane (blue arrows). There is a well known association between suppurative prostatitis and diabetes mellitus

7. Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation (arrows) of the bladder in a man aged 83. Muscle hypertrophy and trabeculation occur because the muscle is working against the obstruction caused by the enlarged prostate.

9. low power view of benign prostatic hyperplasia, with increased stroma and proliferated glands (arrows) present.

11. Prostatic hyperplasia. Hypertrophy of bladder muscle. Cystitis. Bilateral hydroureter and hydronephrosis. Suppurative pyelonephritis.

13. Carcinoma (arrows) arising in the posterior part of the prostate, which is characteristically unaffected by nodular hyperplasia. An incidental autopsy finding in a man aged 78 who died of cerebral infarction.

15. A higher power view of another case of prostatic adenocarcinoma. See how the glands are closely applied to each other (long arrows) and the nuclei are enlarged, hyperchromatic and are more irregularly arranged in the cells (arrowheads).

17. Advanced carcinoma of the prostate.

19. An example of squamous cell carcinoma (arrows) of the penis. Aged 62. Tumour is spreading through the vessels of the corpora cavernosa.

21. Testicular (arrows) atrophy in a man aged 59 with haemochromatosis and cirrhosis.

23. Varicocoele (blue arrows). Appendix of epididymis (red arrow). Hydatid of Morgagni (black arrow) with twisted pedicle: these sometimes separate to form loose bodies. Man aged 58.

25. Haemorrhagic infarction of testis due to torsion of spermatic cord.

27. This is a low power view of a testis which has recently undergone infarction. The longer arrow indicate the tunica albuginea and the smaller arrows show infarcted tubules.

29. Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord. Operative surgical specimen. The twisted portion of the cord is not included.

31. Hydrocoele (blue arrows) in a man aged 72. As is often the case, the cause of the abnormal accumulation of fluid in the tunica vaginalis is not clear. The testis (red arrows) appear atrophic.

33. Chronic haematocoele(blue arrows) in a man aged 43. Testicular atrophy (red arrows) also present.

35. Chronic granulomatous epididymo-orchitisin a man aged 71 with prostatic hyperplasia. The cream nodules (blue arrows) comprise collections of lipid-laden macrophages. Hydrocoele (black arrows).

37. Gumma (arrows) of the testis. This is now n historical specimen from the days when tertiary syphilis was seen. Multiple, irregular areas of necrotic tissue are surrounded by a zone of dense fibrosis. No recognizable testicular tissue remains.

39. Tuberculousepididymo-orchitis, particularly affecting the epididymis (arrows).

41. Seminoma (arrows) of the testis from a man aged 40. This occupies and expands most of the gland. Note that seminomas are a homogeneous cream colour. Testicular tumours usually have a mixture of seminoma and teratoma components.

43. Malignant teratomaof the testis in a man aged 17: operative surgical specimen. As distinct from seminoma, note the very varied macroscopic appearance from one area to another. This is characteristic of teratomas.

45. Immature teratoma of the testis with a choriocarcinoma component. Haemorrhagic necrosis of the latter is characteristic, and results from the tumour cells' propensity to invade blood vessels. The homogeneous white areas are seminoma. Man aged 35 years with "cannon ball" secondaries in the lungs and a positive pregnancy test. The level of HCG in the serum is used as a marker for assessing response to treatment.