360 likes | 853 Views
Lecture 8 ECTOPIC PREGNANCY. ABORTION. Prof. Vlad TICA, MD, PhD. ECTOPIC PREGNANCY. DEFINITION Implantation outside of the uterine cavity
E N D
Lecture 8ECTOPIC PREGNANCY. ABORTION Prof. Vlad TICA, MD, PhD
ECTOPIC PREGNANCY DEFINITION • Implantation outside of the uterine cavity • It is a condition that significantly jeopardizes the mother → catastrophic bleeding may occur when the implanting pregnancy erodes blood vessels / ruptures of the tubal wall
IMPLANT LOCATIONS • Tubal: 95% (80% ampullary portion) • Ovarian: < 1% • Abdominal: 1-2% • Cervical: 0.15% • Cornual: 2%
ETIOLOGY • Salpingitis - 6x increase the risk of ectopic pregnancy • Operation of fallopian tubes • IUD (intrauterine device) • Dysfunction of fallopian tubes • Other: endometriosis
OUTCOMES OF ECTOPIC PREGNANCY • Tubal abortion • 8-12 weeks ampullary portion • Rupture of tubal pregnancy • 5 weeks isthmic portion • Tubal abortion with subsequent implantation • on an intraperitoneal structure, for example liver pregnancy
CLINICAL MANIFESTATIONS • Amenorrhea - 70-80% (6-8 weeks) • Abdominal and pelvic pain - the most common symptom, which is present in nealy all patients • Pain is a result of distented of fallopian tube and irritation of peritoneum by blood • Irregular vaginal bleeding - results from the sloughing of the decidua • Shock - result from amount of blood loss • Abdominal mass
PHYSICAL FINDINGS IN TUBAL PREGNANCY • Anemic / pale face • Pulse ↑↓ • BP ↓ • T < 38 ºC
ABDOMINAL EXAMINATION • Distention and tenderness with or without rebound • Decreased bowel sound • Shifting dullness positive • Mass
PELVIC EXAMINATION • Slightly open cervix with bleeding • Cervical motion tenderness • Adnexal tenderness • Adnexal mass • The uterus size may be normal / enlarged
DIAGNOSTIC PROCEDURES • Typical cases can be determined easy • Early ectopic pregnancy / unruptured type - difficult • It is necessary to need assistant examination
DIAGNOSTIC PROCEDURES • Typical cases can be determined easy • Early ectopic pregnancy / unruptured type - difficult • It is necessary to need assistant examination
DIAGNOSTIC PROCEDURES A. hCG TEST • 80-100% positive • Urinary hCG level • Blood hCG level • If hCG negative, ectopic pregnancy does not be rule out B. TYPE B ULTRASOUND
DIAGNOSTIC PROCEDURES C. CULDOCENTESIS • Aid in the identification of peritoneum bleeding • Positive (noncloting blood) • Ectopic pregnancy may be confirmed • Negative ectopic pregnancy does not be depletion
DIAGNOSTIC PROCEDURES D. LAPAROSCOPY • It is a direct visualization and accurate method to diagnosis ectopic pregnancy • Even laparoscopy - 2-5% misdiagnosis rate • an extremely early tubal pregnancy gestation may not be identified
PATHOLOGY OF ENDOMETRIUM • Curettage of the uterine cavity can also help rule out ectopic pregnancy • Identification of chorionic villi in curetting may identify an intrauterine pregnancy
DIFFERENTIAL DIAGNOSIS • Abortion • Acute salpingitis • Acute appendicitis • Rupture of corpus luteum • Torsion of ovarian cyst
TREATMENT SURGICAL TREATMENT • Salpingectomy • Conservative operation • Salpingostomy • Segmental resection and tubal reanastomosis
TREATMENT CHEMICAL THERAPY • Drug: MTX • Indications: • The diameter of the mass < 3cm • Unrupture • Not significantly bleeding • hCG level < 2000 UI/L
ABORTION DEFINITION • The termination of a pregnancy before 26 weeks from the first day of the last menstrual period
CLASSIFICATION • Early abortion: < 12 wks • Late abortion: 12-28 wks • Spontaneous abortion • Artificial abortion
ETIOLOGY • Genetic factors • Maternal factors • Infection • Systemic factors, heart disease, sever anemia, endocrine • Reproductive tract abnormality • Immunologic factors • Enviromental factors - Toxin, Radiation, smoking, alcohol
PATHOLOGY • Haemorrhage occurs in the decidua basalis leading to local necrosis and inflammation
PATHOLOGY • The ovum, partly or wholly detached, acts as a foreign body and irritates uterine contractions. The cervix begins to dilate.
PATHOLOGY • Expulsion complete. The decidua is shed during the next few days in the lochial flow
CLINICAL MANIFESTATIONS • Haemorrhage • usually the first sign • may be significantly if placental separation is incomplete • Pain • usually intermittent, ‘like a small labrur’ • it ceases when the abortion is complete
THREATENED ABORTION • Low abdominal pain • Vaginal bleeding • Cervix is closed • Unruptured membranes • Embryo survive
INEVITABLE ABORTION • Bleeding increased • Pain development • Rupture of membranes • Cervix dilation • Embryo tissue incarcerated in the cervix
COMPLETE ABORTION • Uterine contractions are felt, the cervix dilates and blood loss continues • The fetus and placenta are expelled complete, the uterus contracts and bleeding stops • No further treatment is needed
INCOMPLETE ABORTION • In spite of uterine contractions and cervical dilatation, only the fetus and some membranes are expelled • The placenta remains partly attached and bleeding continues • This abortion must be completed by surgical methods
MISSED ABORTION • Is the retention of a failed intrauterine pregnancy for a extended period, usually defined as > 2 menstrual cycles RECURRENT ABORTION • The patient has had two / more consecutive spontaneous abortions SEPTIC ABORTION
TREATMENT INCOMPLETE ABORTION • Remove the embryo and placenta as soon as possible • Negative pressure suction • Embryulcia MISSED ABORTION • Notice blood clot function prevent DIC SEPTIC ABORTION • Broad-spectrum antibiotics