MassBio & the Massachusetts BioPharma Cluster

1. MassBio & the Massachusetts BioPharma Cluster

2. About MassBio About MassBio Our Mission: Foster a positive environment that enables each biotechnology company to achieve its full potential, making Massachusetts a world center for biotechnology.

3. About MassBio MassBio represents nearly 620biopharma companies, service providers, academic institutions, hospitals, patient organizations, foreign agencies and other industry stakeholders. The 410+ biopharma members are engaged in a wide spectrum of research & development in life sciences.

4. BioReadyTM Communities Campaign BioReady Communities Campaign Savings from 20 Savings from 20 - 80% % State & Federal State & Federal on everything from on everything from Policy Policy Policy Policy lab gases, lab lab gases, lab equipment, equipment, Purchasing Purchasing Purchasing Purchasing Economic Economic Economic Economic supplies supplies … … Consortium Consortium Consortium Consortium Development Development Development Development MassBio MassBio MassBio MassBio Membership Membership Membership Networking & Networking & Networking & Networking & MassBioEd MassBioEd MassBioEd MassBioEd Visibility Visibility Visibility Visibility Foundation Foundation Foundation Foundation 90+ member meetings, Professional Professional Professional Professional Annual Events Annual Events Annual Events Annual Events 4,100 attendees Development Development Development Development Innovation Services MassCONNECT Pharma Days • Investment • Mentoring • Partnering MassBioEd Courses, MassBioEd Courses, MassBio Committee Meetings MassBio Committee Meetings MassBio Services

5. Savings MassBio negotiates a broad-based collection of contracts and services on behalf of member companies resulting in the most competitive pricing, large volume rebate incentives and specialized customer service

6. Access to the Network Meet new people, learn about trends in the industry, & develop relationships with potential partners at our Forums. • Adventures in Biotech: The Series! • The Billion Dollar Molecule Revisited • Sex, Drugs & Rock & Roll: The story of Viagra • The Use of Social Media in FDA Regulated Business: Impact on Patient Recruitment, Product Marketing & Regulatory Compliance • Catalyzing Innovation – The Critical Success Factors for Pharma-Academia Collaboration • Everything You Wanted to Know About Protocol Violations but were Afraid to Ask

7. Access to the Network Connect with people you have to know & increase your visibility. Annual Events • Open Houses • Supplier Series Trade Shows • Policy Breakfast • Annual Golf Classic Members-Only Resources • HRonline • KnowledgeBase • Careers Portal • Member News • Calendar of Events

8. Business Development Find your next partner, collaborate, and accelerate innovation. • Annual Meeting:Don’t miss our signature scientific event for dynamic keynote presentations, panel discussions, interactive working sessions, poster presentations & extensive networking opportunities (April 3-4, 2014) • MA CRO CMO Symposium: Now in its third year, the Massachusetts CRO/CMO Symposium shines a spotlight on the strength and success of the CRO and CMO communities in the Commonwealth. (May 5, 2014) • BioPharm America:Attend this annual parterning conference & utilize partneringONE (September 2014)

9. Innovation ServicesPharma Days

10. Innovation Services MassCONNECT About MassBio Innovation Services Business Development Access to the Network Savings Advocacy Get Started • Accelerate early stage innovation In depth gap analysis of the business model De-risk opportunities Define market needs • Create Connections within the industry Bio/pharma networks VC and other funding networks • Collaborate with other accelerators and incubators Strong network to identify and source start-ups Referrals to and from other accelerators MassCONNECT mentoring model adopted by BayBio & Indiana Bio

11. MassCONNECT

12. Innovation Services MassCONNECT Cycle I 2014 About MassBio Innovation Services Business Development Access to the Network Savings Advocacy Get Started • AldatuBiosciences • Point of care diagnostic for HIV drug resistance • Resilience Pharma • Novel molecular pathway underlying PTSD • MGH NewCO. • Small molecule therapeutic for VHL disease • GlucoWise • Non-invasive glucometer for Diabetics • Aldatu and Resilience semi-finalists in OneStart • GlucoWise winner MIT/Sloan Building Global Innovators

13. Advocacy About MassBio Innovation Services Business Development Access to the Network Savings Advocacy Get Started Policy: We are the voice of the industry on Beacon Hill & Capitol Hill. Economic Development: We help members with: • Lab & office space • Tax incentives • Grants Workforce Development: We work with our sister organization, MassBioEd on preparing the workforce and filling the pipeline.

14. Advocacy Economic Development & Global Affairs About MassBio Innovation Services Business Development Access to the Network Savings Advocacy Get Started Assisting Companies locate and grow in MA • BioLeads Meetings • Guidance on incentives • Case management • 50+ active leads on average Competitiveness Promoting the Massachusetts Cluster • EDAG Initiatives • BioReady TM Communities • Marketing materials • Trade missions/BIO • Coordination with state agencies Industry Data & Analysis Global Relationships • Annual Industry Snapshot • Industry data for members • 17 Foreign agency members • Host 20 delegations annually MassBio Economic Development & Global Affairs MassBio assists the growth of the biotechnology industry in Massachusetts by: * pursuing strategies to maintain/improve the competitiveness of the cluster; and * providing direct services to biotech companies considering entry to or expansion in Massachusetts.

15. Why Massachusetts? 550 430+ Biopharma Biotech Companies Companies 9 of the Top 18 Top 5 122 122 NIH funded NIH funded Colleges & Colleges & Research Research Universities Universities Hospitals Hospitals 1 1 st st 1 1 st st in in in in Venture Capital Venture Capital Education Education & SBIR funds & federal research Level of Level of per worker funds per worker Workforce (US) workforce Supportive Local, State Government Life Sciences Initiative Biotech Caucus

16. The $1 Billion Massachusetts Life Sciences Initiative – Enacted in 2008 Over time, the industry demonstrated its value, commitment to the region, and promise for the future . . . and state government responded. $250 millionTax Incentive Program $500 million Capital Fund • 10 years • $1 billion Investment $250m Investment Fund (subject to appropriation)

17. III. History

18. Kendall Square, 1960

19. Kendall Square, 1970

20. 60% $564 million

21. 2013 NIH Research Funding - Longwood Medical Area - Boston Brigham and Women’s $315,919,592 Children’s Hospital Boston $126,812,298 Harvard Medical School $200,413,466 Dana Farber Cancer Institute $115,844,948 Beth Israel Deaconess $118,785,811 Harvard School of Public Health $120,611,357 2013 World Series Champions

22. Massachusetts Biotech Timeline Industry History

23. Experienced Leadership: Network Effect in Industry Talent • Predictive Biosciences Hyperion Therapeutics bluebird bio Exact Sciences Corp • Declion Holdings Five Prime Therapeutics • Antigenetics • OvaScience Peptimmune Zyngenia Catabasis • Verastem • FFE Therapeutics Hydra Biosciences rEVO Biologics Candela Aronex Genzyme • Thrombolytic Science International PureTech Ventures • GTC Biothera-peutics GlycoSolutions Cubist OXiGENE • Red Sky Partners Proteon Therapeutics Abazyme Ocular Therapeutix • Link Medical Group Sarepta Flatley Discovery Lab PathoGenetix Novavax • Intercell Procept TetraLogic Viscus Biologics Gallus Biopharma-ceuticals • Columbia Laboratories • Neuron Systems • Aldexa Therapeutics CXO Position after Genzyme 1st 3rd 2nd 4th Note: Representative sample of previous Genzyme employees with CXO title at companies joined after Genzyme. 43 companies excluding Genzyme. Source: Health Advances analysis, LinkedIn.

24. Experienced Leadership : Non-profit Research Acusphere AIR Arsenal BIND Biosciences Blend Therapeutics Echo Therapeutics Enzytech(Acq. by Alkermes) Gecko Biomedica InVivoTherapeutics Kala Living Proof Microchips Moderna Momenta PixarBio Pervasis Pulmatrix Selecta Biosciences Seventh Sense SQZ Biotech Taris Transform T2 Company Creation

25. http://www.polarispartners.com/about/strategy/repeat-entrepreneurs/http://www.polarispartners.com/about/strategy/repeat-entrepreneurs/

26. Networks: Entrepreneurs Associate Professor Harvard Medical School OmidFarokhzad, M.D. Director, Laboratory of Nanomedicine and Biomaterials, Brigham & Women’s Hospital Selecta Biosciences Blend Therapeutics Bind Therapeutics