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Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without Cirrhosis

Explore the efficacy of Glecaprevir-Pibrentasvir treatment for HCV GT 2, 4, 5, or 6 patients without cirrhosis through the results of the SURVEYOR-II (Part 4) study. This fixed-dose combination shows promising SVR12 rates and low adverse events.

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Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without Cirrhosis

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  1. Phase 3 Treatment-Naïve and Treatment-Experienced Glecaprevir-Pibrentasvir for 8 Weeks in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4) Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  2. Glecaprevir-Pibrentasvirin HCV GT 2, 4, 5, or 6without Cirrhosis*SURVEYOR-II (Part 4): Study Features *Note: SURVEYOR-II (Part-4) was published in conjunction with ENDURANCE-2 and ENDURANCE-4 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  3. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Study Design 0 8 20 Week Glecaprevir-Pibrentasvir(n = 203) GT 2, 4, 5, 6 No cirrhosis SVR12 Drug DosingGlecaprevir-pibrentasvir (100/40 mg) fixed dose combination; three pills once daily Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  4. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Baseline Characteristics Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  5. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Baseline Characteristics Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  6. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Results SVR12 (ITT analysis), Overall and by Genotype 189/196 142/145 43/46 2/2 9/10 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  7. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Results SVR12 (ITT analysis), Overall and by Genotype 1lost to follow-up 2 Virologic Relapses; 1 lost to follow-up 3 lost to follow-up 189/196 142/145 43/46 2/2 9/10 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  8. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without CirrhosisSURVEYOR-II (Part 4): Adverse Events Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  9. Glecaprevir-Pibrentasvir in HCV GT 2, 4, 5, or 6 without Cirrhosis*SURVEYOR-II (Part 4): Conclusions *Note: SURVEYOR-II (Part-4) was published in conjunction with ENDURANCE-2 and ENDURANCE-4 Source: Asselah T, et al. ClinGastroenterolHepatol. 2017 Sep 22. [Epub ahead of print]

  10. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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