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Planning a family

Training. Planning a family. prenatal Denk 07.2014. Contents. Prenatal Denk Product Information Key S elling Points Target Group Posology & Administration Ingredients prenatal Denk Folic Acid Iodine Other Micronutrients 6. Planning a Family Together

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Planning a family

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  1. Training Planning a family prenatal Denk 07.2014

  2. Contents Prenatal Denk Product Information Key Selling Points Target Group Posology & Administration Ingredientsprenatal Denk FolicAcid Iodine Other Micronutrients 6. Planning a Family Together 7. Other Denk Nutrition Products 8. Train the Brain – Quiz 9. References

  3. I. prenatal Denk Dietary supplement for folic acid intake before and during the first 12 weeks of pregnancy

  4. 1. prenatal Denk Alu-Alu blisterfoil protectsagainsthumidity

  5. 2. Key SellingPoints • Very good compliance - only 1 tablet per day • One tablet a day covers the recommended daily intake of folic acid and • other micronutrients for the child’s healthy prenatal development • Better absorbed than nutrition folate2 • Daily supplement of folic acid with prenatal Denkprevents birth defects3 • Fast folate status recovery for women who were not able to supplement • folic acid 3 months before conception4 • FDA recommended5 …

  6. 3. Target Group • prenatal D provides all important vitamins and iodine for women during the first 12 weeks of pregnancy. • The intake of prenatal is also recommended for women planning a pregnancy because folate levels should already be adequate at the time of conception.

  7. 4. Posology & Administration • INTAKE • The recommended intake is 1 tablet per day taken with a meal • and plenty of liquid • STARTING DATE • For women before and during the first 12 weeks of pregnancy • Taking folic acid before getting pregnant is essential for reducing birth defects • Neural tube defects develop 18 to 30 days after conception • ( often before women even now they are pregnant) Recommendations START AS SOON AS POSSIBLE

  8. 5. Ingredientsprenatal Denk • Facilitates the sufficient supply of certain micronutritions that are essential for the development of a healthy child • Only 1 coated tablet per day covers the recommended daily requirement of folic acid, iodine and of numerous essential vitamins

  9. a) FolicAcid In the U.S. approximately 2,500 infants are born with a neural tube defect each year. About half of these cases are thought to be related to inadequate folic acid intake by the mother. • Neural tube defects are common birth defects which include: • 1) SPINA BIFIDA • The vertebrae surrounding the spinal cord does not close properly during • the first 28 days after fertitilization => Spinal cord is exposed • A majority of babies born with this condition grow to adulthood with • various degrees of disability (paralysis, inability to control bowel • and bladder bodily function). • 2) ANENCEPHALY • Anencephaly is a condition in which most or all of the brain is absent. • Infants with this condition die shortly after birth http://www.fda.gov/Food/ResourcesForYou/HealthEducators/ucm089330.htm

  10. a) FolicAcid Essential role of folic acid in other physiological functions • DNA synthesis, DNA repair, DNA methylation • Co-factor in biological reactions • Cell division and growth • Production of red blood cells  Prevention of anaemia • Essential for brain functions (mental and emotional health) Other risks linked to folic acid deficiency • Higher risks of heart attacks and stroke • Higher risk of some cancers (e.g. stomach cancer) • Cell division and growth • Considerable decrease in male sperm count and fertility • Higher risk of developing clinical depression [1] The importance of folic acid, Berg et al., J GendSepcif Med, 1999, 2(3): 24-8, [2] http://www.medicalnewstoday.com/articles/219853.php

  11. a) FolicAcid • Humans cannot synthesize folate “de novo” • Special foods help obtain the recommended amount of • folic acid • leafy, dark green vegetables • citrus fruits and juices, berries • legumes (dried beans and peas) • whole grains, breakfast cereals • rice, pasta Excessive cooking can remove or destroy folate contained in food (Folic acid is heat labile!) [1] FDA recommends: 400 µg Folicacidforwomen in childbearingage http://www.fda.gov/Food/ResourcesForYou/HealthEducators/ucm089330.htm …

  12. Train the Brain • Can youlistfunctionsoffolicacid? • DNA synthesis, DNA repair, DNA methylation • Co-factor in biological reactions • Cell division and growth • Production of red blood cells => Prevention of anaemia • Essential for brain functions (mental and • emotional health)

  13. Train the Brain Why should folic acid be supplemented during the first weeks of pregnancy? • Low folate status can lead to birth defects • Spina bifida (neural tube defect) • Anencephaly

  14. a) Why prenatal Denk? • Synthetic folic acid is better absorbed than folate from foods • (1 µg food folate= 0.5 µg supplement folic acid) • Even if a women keeps to a well balanced diet, she may not get • the extra folic acid she needs to prevent birth defects Essential Vitamins 800 µg folic acid A daily amount of at least 600 µg of folic acid, three months prior conception and during the first three months of pregnancy, are recommended. + [1] Achieving a Public Health Recommendation for Preventing Neural tube Defects with folic acid, Martha et al., American Journal of Public Health, 1999, Vol, 89, No 11, 1637-1639 [2] Lamers et al., Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate thant with folic acid in women of childbearing age, Am J ClinNutr 2006, 84(1): 156-161

  15. a) Recommendations [1] Institute ofMedicine. Food and Nutrition Board (1997). Dietary Reference Intakes: Thiamin, Tiboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, PantothenicAcid, Biotin andCholine. Washington, DC, National Academy Press. [2] Dietary DRI Reference Intakes, The Essential Guide toNutritientRequirements, National Academy ofSciences

  16. Train the Brain What is the recommended intake of folic acid during the first trimester of pregnancy? A daily amount of at least 600 µg of folic acid, three months prior conception and during the first three months of pregnancy, are recommended.

  17. a) prenatal Denk • prenatal Denk contains 800 µg of folic acid • The folate status increases faster with 800 µg/d compared to • 400 µg/d1 • Supplementation with 800 µg/d leads to erythrocyte folate • concentration above the neural tube defect cut-off (906 • nmol/L) after 4 weeks and only after 8-12 weeks with 400 • µg/d folic acid.2 Fast folate status recovery (due to high folate concentration) for women who were not able to supplement folic acid 3 months before conception [1]Brämswig S, et al., Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J VitamNutr Res 2009, 79 (2): 61-70 [2]Lamers et al., Red bllood cell folate

  18. b) Iodine • Iodine is essential to produce thyroid hormones which • ensure normal development of the brain and nervous • system before birth and in babies and young children • Iodine Deficiency During Pregnancy and Breastfeeding • Mental retardation (reduced IQ) of newborns • Cognitive delays in newborns • Increased infant mortality Role of Iodine NHMRC Public Statement, Iodine Supplementation forpregnantandbreastfeedingwomen, January 2010 …

  19. b) Iodine • Iodine During Pregnancy • During pregnancy, 50 % more thyroid hormones are • produced • Iodine in Breast-Feeding • Production rate of thyroid hormone returns to normal when • breastfeeding • HOWEVER: Breast fed infants are completely dependent on • milk as a source of iodine ( need around 90-100 µg /d ) To support the mother, foetus and child, iodine intake should be increased 150 µg Iodine FDA recommends: 400 µg Folicacidforwomen in childbearingage http://www.fda.gov/Food/ResourcesForYou/HealthEducators/ucm089330.htm …

  20. b) Recommendation - Iodine The National Health and Medical Research Council (NHMRC) recommends that all women who are pregnant, breastfeeding or considering pregnancy take an iodine supplement of 150 µg/d. 150 µg Iodine

  21. Train the Brain Whyisiodineimportantforthefoetusand theunbornchild? • Iodine is essential for producing thyroid hormones which • ensure normal development of the brain and nervous • system before birth and in babies and young children

  22. c) Other Micronutrients Contributes to maintaining a normal energy metabolism Vit B2 Vit B1 Pantothenic acid Biotin Niacin Reduce tiredness und fatigue Vit B6 Vit B12 Vit E Protection from oxidative stress Vit C Supports the immune system and improves iron resorption … Dietary Supplements duringPreganncy, Schweitzer et al., J PerinatEduc. 2006, 15(4): 44-45

  23. Train the Brain Whatisthetargetgroupofprenatal Denk? • For women during the first 12 weeks of pregnancy • For women planning a pregnancy, because folate • levels should already be adequate at the time of • conception

  24. 6. Planning a FamilyTogether FOR FATHERS -TO-BE may change your (family) life FOR MOTHERS -TO-BE

  25. 7. Other Denk Nutrition Products Well tolerated iron supplement Fast supply of magnesium to muscles, heart and nerves For Iron deficiency in pregnancy & Breast-feeding Reduces cramps during pregnancy Reduction of tiredness & fatigue

  26. 8. Train the Brain – Quiz! What is the target group of prenatal Denk? Why should Folic acid be supplemented during the first weeks of pregnancy? What is the recommended intake of Folic acid during first trimester of pregnancy? List some functions of folic acid? Why is Iodine important for the foetus and newborn child?

  27. 8. Train the Brain – Quiz! • For women during the first 12 weeks of pregnancy, and for women planning pregnancy, because folate levels should already be adequate at the time of conception. • Low folate status can lead to birth defects • Spina bifida (neural tube defect) • Anencephaly • 3. At least 600 µg of folic acid daily for 3 months before • conception and during the first 3 months of pregnancy is recommended. • 4. DNA synthesis, DNA repair, DNA methylation, Co-factor in biological • reactions, Cell division and growth, Production of red blood cells => • Prevention of anaemia, Essential for healthy brain functions (mental and • emotional health) • Iodine is essential for producing thyroid hormones which ensure the normal development of the brain and nervous system before birth and in babies and young children

  28. 9. References • Achieving a Public Health Recommendation for Preventing Neural tube Defects with folic acid, Martha et al., • American Journal of Public Health, 1999, Vol, 89, No 11, 1637-1639 • Lamers et al., Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age, Am J ClinNutr 2006, 84(1): 156-161 • The importance of folic acid, Berg et al., J GendSpecifi Med, 199, 2(3):24-8, [1] Folate recommendation for pregnancy, lactation, and infancy, Lamers Y., University of British Columbia, Faculty of Land and Food Systems • Brämswig S, et al., Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J VitamNutr Res 2009, 79 (2): 61-70 • http://www.fda.gov/Food/ResourcesForYou/HealthEducators/ucm089330.htm • The importance of folic acid, Berg et al., J GendSepcif Med,1999, 2(3): 24-8, • http://www.medicalnewstoday.com/articles/219853.php • Achieving a Public Health Recommendation for Preventing Neural tube Defects with folic acid, Martha et al., American Journal of Public Health, 1999, Vol, 89, No 11, 1637-1639 • Lamers et al., Red bllood cell folate concentrations increase more after supplementation with [6S]-5- methyltetrahydrofolate than with folic acid in women of childbearing age, Am J ClinNutr 2006, 84(1): 156-161 • Institute of Medicine. Food and Nutrition Board (1997). Dietary Reference Intakes: Thiamin, Tiboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. Washington, DC, National Academy Press.

  29. 9. References • Dietary DRI Reference Intakes, The Essential Guide to Nutrient Requirements, National Academy of Sciences • Omega-3 fatty Acid Supplementation During Pregnancy, Greenberg et al., Reviews in Obstetrics & Gynecology, Vol. 1 No 4. 2008 , 162-169 • Folate recommendation for pregnancy, lactation, and infancy, Lamers Y., University of British Columbia, Faculty of Land and Food Systems, Rev Obstet Gynecol. 2010 Fall; 3(4): 163–171. • Omega-3 fatty acid supplementation During Pregnancy, Greenberg et al., MED REVIEWS; Vol 1 No 4, 2008 • Global Recommendations for EPA and DHA intake (Rev 16 April 2014) • Wallock et al., FertilSteril 2001, 75 (2): 252-9 • Suleiman et al., J Anrol 1996, 17: 530-7 • World Health Organization reference values for human semen characteristics, Cooper et al., Human Reproduction, Update, Vol 16, No 3, 231-245, 2010 • American Society for Reproductive Medicine, http://www.asrm.org/detail.aspx?id=2322 • http://www.mayoclinic.org/diseases-conditions/male-infertility/basics/causes/con-20033113 • Male infertility, Proposed treatments for male infertility, EBSCO CAM Review Board, 2011 • Walnuts improve Semen Quality in Men Consuming a Western-style Diet: Randomized Control Dietary Intervention Trial, Robbins et al., Biology of Reproduction, 2012 • http://www.beliefnet.com/healthandhealing/getcontent.aspx?cid=157009, Oldereid et al., Lifestyles of men in barren couples and their relationships to sperm quality, Eur J ObstetGynecolReprodBiol, 1992 Jan 9;43(1):51-7.

  30. Join Denk Pharma! Our contributions to keeping you* healthy: • affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, • packaging, studies, consultation, availability, support, etc… • raise awareness by conducting Check Up Days (blood glucose, • blood pressure, cholesterol and triglyceride) • constantly enhancing the product portfolio *patients, doctors, pharmacists, sales reps

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