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Abciximab plus heparin versus bivalirudin : ISAR-REACT-4.
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Abciximab plus heparin versus bivalirudin: ISAR-REACT-4 Objective: to evaluate the efficacy of abciximab plus heparin versus bivalirudin in patients with non-ST-elevation MI undergoing PCIStudy: multicenterdouble-blindrandomizedcontrolled trialPopulation: patients withnon-ST segment elevation MI undergoing PCI Endpoint: composite death, re-MI, urgent TVR or major bleedingat 30 days
Abciximab plus heparin versus bivalirudin: ISAR-REACT-4 Conclusion abciximab plus heparinwasassociatedwithsimilar major adverse events as bivalirudin. The major bleeding rate waslowerwithbivalirudin. Kastrati NEJM 2011;365:1980-9