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EPIC: Balloon Angioplasty

Placebo + heparin (ACT  300 sec) (n=696). Abciximab 0.25mg/kg bolus + heparin (ACT  300 sec) (n=395). Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT  300 sec) (n=708). EPIC: Balloon Angioplasty. Primary Endpoint: Death, MI, UTVR at 30 days. 4.5%  ( P <0.004).

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EPIC: Balloon Angioplasty

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  1. Placebo + heparin (ACT  300 sec)(n=696) Abciximab 0.25mg/kg bolus + heparin (ACT  300 sec)(n=395) Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT  300 sec)(n=708) EPIC: Balloon Angioplasty Primary Endpoint: Death, MI, UTVR at 30 days 4.5% (P<0.004) 1.4% (P=ns) %events 12.8% 11.4% 8.3% The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.

  2. 30 DayDeath/MI3.5% (P=0.015) 6 MonthDeath/MI3.9% (P=0.019) 30 DayTVR3.8% (P=0.003) 6 MonthTVR5.8% (P=0.007) Placebo + heparin (ACT  300 sec)(n=696) Abciximab + heparin (ACT  300 sec)(n=708) 22.3% MajorTIMIBleeding 16.5% 12.8% 9.6% 8.9% 7.8% 6.6% 6.1% 4.0% 1.4% EPIC Results %events The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.

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