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B Cell Maturation, Activation & Differentiation

B Cell Maturation, Activation & Differentiation. Hugh B. Fackrell Jan 4 ,1998. B Cell Maturation, Activation & Differentiation. Assigned Reading Content Outline Performance Ojectives Key terms Key Concepts Short Answer Questions. Assigned Reading. Chapter: 8 pp 195-222

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B Cell Maturation, Activation & Differentiation

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  1. B Cell Maturation, Activation & Differentiation Hugh B. Fackrell Jan 4 ,1998

  2. B Cell Maturation, Activation & Differentiation • Assigned Reading • Content Outline • Performance Ojectives • Key terms • Key Concepts • Short Answer Questions

  3. Assigned Reading • Chapter: 8 pp 195-222 • Janis Kuby’s Immunology 3rd Ed

  4. Content Outline • B Cell Maturation • B Cell Activation & Proliferation • In Vivo induction of Humoral Response • B Cell Differentation • Regulation of B Cell Development

  5. B Cell Maturation • Bone marrow • Ig Gene rearrangements • Pre B cell receptor • Selection of Immature Self Reactive B Cells • negative selection • rescue editing of light chain genes

  6. B Cell Activation & Proliferation • T dependent vs T independent antigens • Origins of activating signals • Transduction of Activating signals • B cell coreceptor complex • T helper cells • formation of T-B conjugate • mediation by CD40 • induction of progression signals • Negative selection

  7. In Vivo Induction of Humoral Response

  8. B Cell Differentation • Affinity maturation • somatic hypermutation • antigen selection • Class switching • Plasma cells • Memory cells

  9. Regulation of B Cell Development

  10. Performance Objectives

  11. Key Terms • affinity maturation, apotosis, avidity, capping, carrier effect, cell mediated immunity,Cytotoxic T cells, Helper T cells, TH1 cells, TH2 cells, humoral immunity, immunologic memory, perforin, plasma cells, primary antibody, programmed cell death, secondary antibody, thymus dependent antigens, thymus independent antigens

  12. Key Concepts • Describe the sequential development of the humoral immune response. • Draw a contemporary model for T cell B cell macrophage interaction • Describe antigen processing and presentation by B cells

  13. Outline the sequence of helper (T/(TH) cell involvment in antibody production • Describe the interplay between TH1 and Th2 cells in the development of immune responses

  14. Short Answer Questions

  15. DONE!!!

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