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Tissues of the Immune Response

Explore the intricate network of primary and secondary lymphoid tissues, such as bone marrow and thymus, where lymphocytes are generated and matured. Learn about the role of lymph nodes, spleen, and mucosal-associated lymphoid tissues in immune responses.

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Tissues of the Immune Response

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  1. Tissues of the Immune Response Hugh B. Fackrell Filename:tissuesv7

  2. Structure and Function of the Lymphatic System • Lymphatic system • Primary Lymphoid tissues • Secondary Lymphoid Tissues • Next

  3. Lymphatic System: Function • Generate lymphocytes committed to a particular antigenic specificity • Create an environment to trap antigens from various tissues, spaces or fluids • Provide sites where the committed lymphocytes interact with the trapped antigens • Next

  4. Committed Lymphocytes • Immature lymphocytes • generated by hematopoiesis of pleuripotent stem cells within the bone marrow. • Lymphocytes mature in the primary lymphoid organs • Bone Marrow, Thymus, Bursa (in birds) • Mature lymphocytes migrate to the secondary lymphoid organs • Lymph nodes, spleen, mucosal associated lymphoid tissues

  5. Primary Lymphoid Tissues • B cells • Birds • Bursa of Fabricius • Mammals • Fetal Liver • Bone Marrow • T Cells • Thymus

  6. Bursa • Location • Structure • Function

  7. Avian Lymphoid System

  8. Bursa of Fabricius:Follicles

  9. Bursa of Fabricius: X-Section

  10. Bursa: B cell germinal centers

  11. B cell Origins • Hemopoietic stem cells develop in the fetal liver • Later they are produced in the Bone Marrow • “Bursal equivalent” • Next

  12. Fetal liver: Hematopoiesis

  13. Bone Marrow Scanning EM

  14. Bone Marrow Differentiation

  15. Thymus • Location • Structure • Circulation • Function • Summary Diagram

  16. Thymus: Location

  17. Thymus: Lobules

  18. Thymus: X section

  19. Thymus: Development

  20. Thymus: Embrogenisis

  21. Thymus: Summary Diagram

  22. Athymic Mouse • “Nude” mouse - lacks hair follicles • Lacks developed thymus • few circulating T cells • No cell mediated immunity

  23. “Nude Mouse”

  24. Lymph Nodes • Distribution • Structure • Circulation • Function • Summary Diagram

  25. Lymphatic System

  26. Node: Circulation

  27. Node: TD & TI areas

  28. Capsule Cortex Paracortex Medulla Node: X section

  29. Node: Diagram 2

  30. Cortex

  31. Node: Diagram Primary Follicle Efferent lymphatic Afferent lymphatic

  32. Node: B cells in cortex

  33. Node: Germinal Center

  34. Node: Reticular network

  35. Node Follicle: Mantle of lymphocytes

  36. Paracortex

  37. Node T Cells Diffuse cortex

  38. Node: T Cells in Paracortex

  39. Node: T cell depletion

  40. Medulla Thymic Dependent area T cells localize

  41. Lymph Node: Medulla

  42. Node: LM Medulla

  43. Node: Medullary Sinus

  44. Node: Subcapsular Sinus

  45. Node: EM of Medulla

  46. Node: Primary Follicle

  47. Node: Diffuse Cortex

  48. Node: HEV

  49. Node: Diagram summary

  50. Spleen • Location • Structure • Circulation • Immunological function • Summary Diagram

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