The History of Lactate and its Modern Implications

1. The History of Lactateand its Modern Implications Odessa Addison, DPT 9/28/2009

2. History of Lactate • 1808-Lacte identified by Berzelius • 1891-Araki identified lactate concentrations rise in proportion to activation of exercised muscle. Thought this was related to oxygen availability.

3. History of Lactate • 1907- Fletcher and Hopkins looked at lactate in amphibian muscle • Lactic acid appeared in response to muscle contraction in absence of oxygen • Lactate disappeared when oxygen was present

4. History of Lactate • 1920’s-Hill, Heidelberg, and Margaria groups • Identification of lactic acid cycle • Aerobic and anaerobic pathways for cellular energy supplies • Rise of lactic acid at onset of exercise as result of oxygen deficit • Correlations of increased lactate and decreased twitch force

5. Lactate Correlates to Decreased Twitch Force Force Lactate

6. History of Lactate • “After these findings science sought to prove lactate was the cause of fatigue rather then to question its function” ----Philp et al

7. After Lactate is produced how is it utilized? ICLS