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What is the WHO classification for non-Hodgkin lymphoma? 10 Precursor B cell neoplasms

What is the WHO classification for non-Hodgkin lymphoma? 10 Precursor B cell neoplasms Peripheral B cell neoplasms Percursor T cell neoplasm Peripheral T cell and NK cell neoplasm. What is the difference between leukaemia and lymphoma? 1 …. WHO classification for Hodgkin’s lymphoma.

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What is the WHO classification for non-Hodgkin lymphoma? 10 Precursor B cell neoplasms

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  1. What is the WHO classification for non-Hodgkin lymphoma? • 10 • Precursor B cell neoplasms • Peripheral B cell neoplasms • Percursor T cell neoplasm • Peripheral T cell and NK cell neoplasm

  2. What is the difference between leukaemia and lymphoma? • 1 • …

  3. WHO classification for Hodgkin’s lymphoma. • 10 • Nodular sclerosis • Mixed cellularity • Lymphocyte rich • Lymphocyte depletion • Lymphocyte predominance

  4. What type of Hodgkin’s lymphoma is most commonly associated with HIV and EBV? • 15 • Lymphocyte depletion.

  5. Clinically features of a patient with NHL. • 1 • Painless, generalised lymphadenopathy.

  6. You have a patient who has just presented, you think they may have HL, how likely are they to have B symptoms? • 20 • Commonly just present with painless lymphadenopathy. • Nodular sclerosis and lymphocyte predominance are usually free of systemic symptoms (usually present stage 1 or 2). • Stages III – IV, or mixed cellularity, or lymphocyte depletion are more likely to have B symptoms.

  7. What proportion of lymphoid neoplasms are from B cells? What are the other cells of origin? • 5 • 80-85% • Most of the remainder are T cells, NK cells are quite rare.

  8. Different types of euthanasia. • 1 • Active voluntary • Non-voluntary • Involuntary • Passive

  9. Arguments in favour of euthanasia. • 1 • Autonomy. • Dignity. • Compassion. • Difference between active assistance to die and allowing a person to die is morally irrelevant. • Already occurring. • Palliative care is insufficient. • ..

  10. Arguments against euthanasia. • 1 • Life is sacred. • Morale difference between killing and letting someone die. • Slippery slope. • Procedural safeguards against abuses are impossible to forsee. • Adequate palliative care services already exist. • …

  11. Describe the process of giving bad news through the use of an acronym. • 0 • Setting • Perception • Invitations • Knowledge • Explore and empathise • Strategy and summary

  12. What are we looking for on observation for a haematological examination • 10 • General appearance • racial origin, • pallor, • bruising, • jaundice, • scratch marks

  13. What is the pathophysiology of tumorlysis syndrome? • 10 • Lysis of tumor cells. • Release of intracellular contents. • Renal failure, multiple organ failure, death.

  14. Clinical manifestations of hypercalcaemia. • 15 • Fatigue, anorexia, constipation, vomiting • Vomiting, confusion, thirst and polyuria • Coma, arrhythmia

  15. Aetiology of hypercalcaemia. • 15 • Primary hyperparathyroidism • Malignancy • Drug therapy • Tourniquet artefact • Sarcoidosis

  16. What is of primary concern here. • 10

  17. Outline where the hyoid bone would be. • 5

  18. Give me four causes of spleen enlargement. • 1 • Portal hypertension (cardiac failure?) • Lymphoma • Anaemia • Metabolic

  19. What are the immediate and long term complications of lymphoma treatment? • 5 • Immediate – nausea, vomiting, inflmaation and ulceration of mucus membranes, alopecia, pancytopenia • Long term – 2degree malignancies, fertility, thyroid, hepatic or renal function

  20. What variant of Reed-Sternbery cell occurs in Nodular sclerosis Hodgkin’s lymphoma? • 50 • lacunar

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