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Section 3 Inflammatory Mediator

Section 3 Inflammatory Mediator. 1. Definition: It is the chemical substances which cause or participate in inflammation (1) Mediators originate either from plasma or cells

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Section 3 Inflammatory Mediator

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  1. Section 3 Inflammatory Mediator

  2. 1. Definition: It is the chemical substances which cause or participate in inflammation (1) Mediators originate either from plasma or cells (2) Most mediators perform their biologic activity by initially binding to specific receptors on target cells. (3)A chemical mediator can stimulate the release of mediators by target cells themselves.

  3. (4) Mediator can on one or few target cell types, or have widespread targets, or may even have differing effects, depending on cell and tissue types. (5) Once activated and released from the cell, most of these mediators are short-lived (6) Most mediators have potential harmful effects.

  4. 2. Types of mediator (1) Cell produce • serotonin • Arachidonic acid metabolic products: LTB4、LTC4、LTD4、LTE4 • Cell products: O2-, H2O2, acid protease, neutral proteinase. • Cytokine: IL-1β, 2,3,4,6,7,10,12, IFN-γ, TNF-α, CSF. • Platelet activating factor( PAF) • nitric oxide(NO)

  5. 2. Types of mediator (2) body fluid produce • Kinin system • Complement system • Clotting system

  6. 2. Types of mediatorSummary of mediators of acute inflammation

  7. Main mediators function

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