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Beamline 8.3.1

Beamline 8.3.1. PRT organization Funding Hardware Safety management Control system Scientific productivity. Beamline 8.3.1. PRT organization Funding Hardware Safety management Control system Scientific productivity. 25%. 25%. UC Berkeley. 2%. Plexxikon. 8%. General User

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Beamline 8.3.1

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  1. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  2. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  3. 25% 25% UC Berkeley 2% Plexxikon 8% General User Program 5% 25% 10% Beam Time Allocation

  4. Staff PRT Member Labs PRT Contractees Tom Alber Principal Investigator James Holton Beamline Director George Meigs Senior Research Associate Jane Tanamachi Administrator

  5. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  6. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  7. Funding for ALS 8.3.1

  8. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  9. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  10. X-ray optics Superbend Scatter guard pinhole Plane Parabolic mirror Torroidal mirror ADSC Quantum 210 divergence slits Si(111) monochromator Protein Crystal • 2:1 demagnification cancels spherical aberrations • comparable flux to a wiggler with < 1% of the heat

  11. ADSC Quantum 210 X-ray optics Superbend Scatter guard pinhole Plane Parabolic mirror Torroidal mirror divergence slits Si(111) monochromator Protein Crystal • 2:1 demagnification cancels spherical aberrations • comparable flux to a wiggler with < 1% of the heat

  12. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  13. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  14. Safety Management • Hardware safety systems • Training • Safety through simplicity • Failsafe envelope • Examples: • Liquid nitrogen – better tools • Automatic retraction – eliminate confusion • Automatic backup – eliminate distraction

  15. Safety Envelope Radiation Safety System (RSS) Personnel Protection System (PSS) Equipment Protection System (EPS) GERT Training 8.3.1 Training experiment

  16. Safety Envelope Radiation Safety System (RSS) Personnel Protection System (PSS) Equipment Protection System (EPS) GERT Training 8.3.1 Training experiment

  17. Safety Envelope “There is no safety system that can stop a determined user with a hacksaw” -Anonymous Solution: Create tools that enhance productivity within the safety envelope

  18. Example 1: Liquid nitrogen

  19. Liquid nitrogen safety concern

  20. A safer way

  21. Safer and more productive!

  22. ADSC Quantum 210 Example 2: Automatic detector retraction

  23. ADSC Quantum 210

  24. ADSC Quantum 210 Detector retraction

  25. ADSC Quantum 210 Detector retraction

  26. Automatic detector retraction • Detector motors are disabled with hutch door open (pinch hazard) • Sample is difficult to access with detector in data collection position • Common mistake: • forget to retract detector before opening door • Result: confusion • Solution: • Door will not open with detector forward • Detector automatically retracts on door open attempt

  27. 1.8 1.8 1.6 1.6 Distraction Distraction Condition Condition 1.4 1.4 Median time to lift foot Median time to lift foot off accelerator (secs.) off accelerator (secs.) 1.2 1.2 No No - - Distraction Distraction Condition Condition 1.0 1.0 0.8 0.8 2 2 4 4 6 6 8 8 Distance from the Distance from the lead vehicle (secs.) lead vehicle (secs.) Distraction is unsafe! Drivers following a car that suddenly brakes take longer to respond to that event when they are distracted by trying to solve a logic problem. This is especially true if the two vehicles start out close together--when it is critical that the driver in the following vehicle make a rapid response to avoid a rear-end collision.

  28. Automated firewire drive backup

  29. Automated DVD archive

  30. Safety Summary • Encourage safe practices by making them the best way to get results • Measures are in addition to existing ALS safety envelope • Better science and better safety can go hand in hand

  31. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  32. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  33. Software BLU-ICE 3.0 control system Elves integrated with BLU-ICE ALS-wide beamline health monitor

  34. Touch screen

  35. Elves structure solution data collection Integration of Elves with BLU-ICE index most recent image Wedger Elves run information mosflm autoindex strategy

  36. Elves structure solution data collection Integration of Elves with BLU-ICE process run information pick un-busy cluster node mosflm scala solve ARP/wARP

  37. Elven Automation Apr 6 – 24 at ALS 8.3.1

  38. Elven Automation Apr 6 – 24 at ALS 8.3.1

  39. ALS beamline health monitor

  40. ALS lN2 health monitor

  41. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  42. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity

  43. AmtB ammonia channel Khademi et. al. (2004) Science305 1587-94.

  44. The E. coli ribosome Schuwirth et. al. (2005) Science 310 827-34

  45. DnaA origin-recognition protein Erzberger et. al. (2006) Nat Struct Mol Biol13, 676-83

  46. E. coli rho Skordalakes and Berger (2003) Cell114, 135

  47. multidrug transporter EmrD Yin et. al. (2006) Science312 741-4

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