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Obstetrics Nuala Lucas OAA

Explore findings on severe obstetric perioperative anaphylaxis from NAP6 survey with key recommendations for management and outcomes. Learn about presentation, culprits, and institutional measures for safer obstetric anesthesia practice.

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Obstetrics Nuala Lucas OAA

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  1. ObstetricsNuala LucasOAA

  2. What we knew before NAP6 • Had received very limited prospective examination • available knowledge case reports/series & reviews

  3. Specific concerns for obstetrics Broad differential diagnosis Two ‘patients’ Latex allergy?

  4. Obstetric cases 8 cases identified NAP6 Activity Survey estimated 233,886 obstetric anaesthetics are administered PA in UK Incidence of severe obstetric perioperative anaphylaxis of 3.4 per 100,000 (95% CI 1.48-6.74 per 100,000) 6 cases associated with neuraxial anaesthesia, 2 cases associated with general anaesthesia

  5. Presentation 4/6 patients who developed anaphylaxis assoc with neuraxial anaesthesia complained of feeling unwell prior to the onset of hypotension or other clinical signs ‘New’hypotension In 4 cases (both GA and 2/6 neuraxial cases) there was prompt recognition of the clinical event Only one case (neuraxial anaesthesia) was the event promptly recognised as anaphylaxis

  6. ‘New’ hypotension

  7. Management

  8. Management

  9. Outcomes Post event • No cardiac arrests • Aftercare • ITU/Recovery/Operating theatre/Observation bay on LW – 2/2/2/2 • 3/5 delayed hospital discharge • One woman reported anxiety re future anaesthetics Baby • 5/6 caesarean section cases – onset after delivery of baby • 1/6 onset immediately before delivery of baby

  10. Culprits

  11. Recommendations • Institutional Obstetric units should ensure immediate availability of anaesthetic anaphylaxis treatment and investigation packs wherever general or regional anaesthesia is administered • Individual An allergy history should be taken even when there is extreme urgency to deliver the baby Anaesthetists should be vigilant to non-obstetric causes of hypotension in obstetric patients Anaphylaxis should be actively considered where the cause of maternal hypotension or collapse is unclear, and mast cell tryptase levels should be measured Anaphylaxis in obstetric patients should be managed following the same principles as in non-obstetric patients. Anaesthetists should be aware that hypotension due to anaphylaxis can be exacerbated by neuraxial blockade and or aortocaval compression

  12. Other findings - choice of induction agent

  13. Any questions?

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