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Welcome to the Molecular Medicine course!

Welcome to the Molecular Medicine course!. Registration. General information Over-arching goals Roll call Course contents Information about KS library Coffee Course evaluation HT 2011 Study design - research application + presentations Seminar assignment Final examination

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Welcome to the Molecular Medicine course!

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  1. Welcome to theMolecular Medicinecourse!

  2. Registration • General information • Over-arching goals • Roll call • Course contents • Information about KS library • Coffee • Course evaluation HT 2011 • Study design - research application + presentations • Seminar assignment • Final examination • Molecular Medicine - from bed to bench

  3. Course leader: Rachel Fisher 08-517 732 45 rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91 ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course administrator: Eva MacDonald Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 08-517 716 33 eva.macdonald@ki.se Office hours daily 8.00am - 3.00pm

  4. Over-arching goals • To integrate previously gained knowledge • To stimulate team work • To analyse, evaluate and interpret raw data • To design a study and write a research application • To provide “real life” experience

  5. Roll call

  6. Course set up • Lectures usually 9am – 3pm (check venue!) • Labs/demonstrations/seminars usually in groups • Time scheduled for group work • Seminar assignment • Presentation of group work (research application) at end of course • Revision time • Final written examination: 15th January

  7. Course contents (15 hp/ECTS) • Specific areas • Circulation, ischemia, metabolic syndrome, diabetes • Respiration, asthma, allergy • Endocrinology • Gastroenterology • Pathology • Clinical immunology / Clinical chemistry • Assignments etc. • Molecular biology lab • Research application • Seminar assignment • Workshops • Revision

  8. Course literature • Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology • Articles and links on the web page • Lecture summary points (from lecturers)

  9. Information about KS libraryMarie Källberg

  10. Seminar assignment Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Workshops Research plan

  11. Labs and Demonstrations • Lab: “Methods in Molecular Biology – Theory and Practice” • 12/11 (introduction) 27-29/11, 4-6/12 (lab) 12-14/12 (analysis + statistics) 9/12 (discussion + review) • Angiography demonstration (14/11) • Blood grouping lab (15-16/11) • Lung/allergy demonstration (20/11)

  12. Labs • You must bring your own lab coatCompulsory to have a lab coat to perform the labs • If you have lost the lab coat you were given when you started the Biomedicine Programme, you can buy a new one (380kr):http://www.g-ess.se/ Tel: 08-449 85 70 (Stuvsta + Bromma) • Some labs and demonstrations will be performed in active research labs- show consideration for those who work there

  13. Blood groupingThur 15/11,9–12 • Methods Mol BiolTue 27/11 Groups • Blood groupingFri 16/11,9–12 • Methods Mol BiolWed 28/11 • Blood groupingThur 15/11,13–16 • Methods Mol Biol • Tue 4/12 • Blood groupingFri 16/11,13–16 • Methods Mol Biol • Wed 5/12

  14. Course evaluation HT 2011 Good • Research application • Lab “Methods in Molecular Biology” • Seminar assignment • Course leaders/administration Mixed • Clinical emphasis • Blood grouping lab • Lung/asthma/allergy demonstration • Lecturers Bad • Lack of a course text book • Some repetition within lectures • Too many lectures

  15. New for HT 2012 • Some lectures + pathology seminars removed • Workshops • Modified set up for Lab “Methods in Molecular Biology” • Place blood grouping lab in context • Modified lung/asthma/allergy demonstration • Final examination after Christmas • Presentation of research applications at end of course

  16. Workshops • 3 workshops: Atherosclerosis (12/11) Endocrinology (21/11) Diabetes/Metabolism (11/12) • Questions/discussion topics handed out in connection with relevant lectures • Self-study/discussion + review with teacher • Preparation for the exam

  17. Evaluation of the course • We rely on your feedback to improve the course • Please give constructive feedback • Evaluation forms (online) • Cinema ticket voucher if all evaluation forms completed + submitted!

  18. Course councils • With class representatives Wednesday 21st November, 12 noon • With whole class Thursday 17th January, 3pm • Who are the class representatives?

  19. Forms of feedback reviewing progress with  students Round-table feedback  Methods in mol biol Research application feedback on seminar assignment & exam Peer-to-peer to edit and redraft  Methods in mol biol Pre-submission guidance and feedback  Research application Workshops feedforward assignments  Research application Informing about feedback whole-class feedback  Workshops Course councils and evaluations

  20. Course language • All literature in English • Lectures in English • All assignments may be written in either English or Swedish

  21. Research application • Group assignment • Choose a specific issue to focus on • Design a research project • Write a research application • Present the project orally • Answer questions • Team work • Realistic exercise

  22. Research application:groups and topics • Groups 1-6 each split in 2 • 12 ”subgroups” of 3-4 people • Each subgroup allocated a broad topic • Detailed project chosen by the subgroup • Discussions with and feed back from topic ”mentor”

  23. MicroRNA and vascular disease Aneurysm Thyroid diseases Thrombosis and haemostasis Mesenchymal stem cells and bone formation Cell death in metabolism Metabolism and cardiovascular disease Immunological aspects of gastric disease Inflammation in cardiovascular disease Allergy Diabetes and co-morbidities Vascular remodelling Research application – broad topics 2 topics/group, 3-4 people/research application

  24. Research applicationtopic lottery

  25. Seminar assignment • Handed out at course start • Group work / individual assessment • Research based aspects, requires independent work • Obtain appropriate information- lectures, discussions, web, articles ..… • Time scheduled to prepare answer • Presentation of assignment in seminar format:Groups 4, 5 + 6 Wednesday 28th NovemberGroups 1, 2 + 3 Wednesday 5th December • Grading = pass / fail

  26. Time in schedule for Groups 1, 2 + 3to work with seminar assignment

  27. Time in schedule for Groups 4, 5 + 6to work with seminar assignment

  28. Examination • Final examination: Tuesday 15th January Grades A-F • Questions testing knowledge + understanding

  29. Grading of the examination • F, Fx, E, D, C, B, A • Goal-based assessment • Evaluating the level of knowledge obtained not the amount of knowledge • F, Fx = fail • E = basic pass: identify, describe, list • C, D = pass with merit: compare, explain connections, analyse, apply • B, A = pass with distinction: theorise, hypothesise, reflect

  30. One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain Extended abstract B, A Relational C, D Prestructural F Multistructural E Unistructural Fx

  31. To pass the course … • The student must obtain a grade of at least E for the written examination (5 hp) • The student must also pass • the seminar assignment (3 hp) • the research application (3 hp) • all labs and demonstrations (4 hp)

  32. Replacement assignments • When compulsory parts of the course are missed, there are replacement exercises • If written, these must be handed in by the last day of the course (18 January 2013) • Next opportunity for submission = next course (HT2013)

  33. Information about Masters Programme • Wednesday 21st November, 1pm Lars-Arne Haldosén Lena Hansson

  34. Molecular Medicine:from bed to bench • Important clinical contact • Translational research • Cross-disciplinary • “From bench to bed and back again”

  35. Please use the web page!

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