1 / 4

Topic

Topic. Proposed project: neutrotoxin Fasciulin Found in snakes such as the Green and Black Mamba. Explanation. Fasciculin is known to inhibit reversibly mammalian and fish acetylcholinesterases at picomolar concentrations. What is a toxin? Find more about acetylcholinesterases .

riva
Download Presentation

Topic

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Topic • Proposed project: neutrotoxinFasciulin • Found in snakes such as the Green and Black Mamba.

  2. Explanation • Fasciculin is known to inhibit reversibly mammalian and fish acetylcholinesterases at picomolar concentrations. • What is a toxin? • Find more about acetylcholinesterases. • Look in reversible inhibitors. • Should indicate functional groups. • Structural information • Fasciculin-II (FAS-II) is a 61-residue polypeptide, three fingered toxin purified from green mamba venom. • What is a three fingered toxin? • How do these disulfides work in this neurotoxin?

  3. Needed Background Information • Examine function of acetylchoine. • Need to understand more at the molecular level. • How would an antivenom work for this neurotoxin at the molecular level? • How does fasciclininterfer with the normal binding process of acetylcholinesterase (AChE)? What does it change?

  4. Why? • Give explanation of what made you interested in the project? • Heard an explanation of this toxin in Kill Bill Volume 2.

More Related