2013 GPCR Screening and Profiling Trends Market

1. GPCR Screening & Profiling Trends 2013 Order this report by calling +1 888 391 5441 or Send an email to sales@reportsandreports.com with your contact details and questions if any. Published: August 2013 Single User PDF: US$ 2500 Corporate User PDF: © ReportsnReports.com / Contact sales@reportsandreports.com

2. GPCR Screening & Profiling Trends 2013 This market report summarizes the results of HTStec's 5th industry-wide global web-based benchmarking survey on GPCR screening and profiling carried out in August 2013. The survey was initiated by HTStec as part of its tracking of life science marketplaces. The questionnaire was compiled to meet the needs, requirements and interests of the GPCR vendor community. The objectives were to comprehensively document current practices and preferences in GPCR primary screening and compound profiling, and to understand future user requirements, particularly with respect to the need for new assays, approaches and the use of outsourced services. The aim was to compile a reference document on GPCR screening and profiling metrics, which could be directly compared with HTStec's previous reports (the last one on GPCRs was published in October 2010). Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research market segments in both North America and Europe. Complete report available @http://www.reportsnreports.com/reports/267694-gpcr-screening-profiling-trends-2013.html The survey looked at both in house and outsourced GPCR primary screening and compound profiling, as practiced today (2013) and in some cases as predicted for the future (2015). Specifically the following were investigated: whether the number of GPCR primary screening targets or programs under investigation is changing; the proportion of GPCR screens that are cell-based and orphan receptors; use of different methods for assaying GPCR activation; preferred assay readout technology and supplier for GPCR screening; proportion of GPCR Ca2+ flux assays that are fluorescence-based; number of GPCR primary screens and wells per screen; approach to GPCR profiling; preferred assay readout technology and supplier for GPCR profiling; size of in house profiling panels and total wells profiled in house per year; how receptor panels are chosen; level of interest in outsourcing; methods of assaying GPCR activation that respondents wish to access by outsourcing; type of GPCR panels most interested to access at a fee-for-service provider; typical sizes of outsourced GPCR profiling panels used and total wells profiled per year at a fee-for-service providers; most trusted and most used providers of outsourced Order this report by calling +1 888 391 5441 or Send an email to sales@reportsandreports.com with your contact details and questions if any. © ReportsnReports.com / Contact sales@reportsandreports.com

3. GPCR Screening & Profiling Trends 2013 Most survey respondents had a senior job role or position which was in descending order: 17 senior scientists/researchers; 17 principal investigators; 13 research scientists; 13 professors/assistant professors; 8 directors; 7 section/group leaders; 7 department heads; 1 graduate/PhD student; 1 vice president; and 1 outsourcing manager. Inquire for discount @ http://www.reportsnreports.com/contacts/Discount.aspx?name=267694 Respondents main group activities were: 27 basic research; 23 a combination of drug discovery roles; 11 assay development; 10 primary screening (HTS); 8 applied research; 7 hits-to-leads (lead optimization); 6 therapeutic areas; 2 secondary screening; and 2 compound profiling. Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was fully reanalyzed after sub-division into the following 5 survey groups: 1) Pharma; 2) Biotech; 3) Academic Research; 4) Europe; and 5) North America. The median number of GPCR primary screening targets/programs under investigation in 2013 was 3. 70% of GPCR primary screens were cell-based and 17% were orphan receptors in 2013. In 2013 the relative use of different methods used to study GPCR activation was: 24% binding assays; 16% cAMP or cGMP assays; 13% Ca2+ flux/mobilization assays; 12% β-arrestin recruitment or receptor internalization; and 11% reporter gene assays. All other methods had less than 10% use. The preferred GPCR readout technologies and suppliers for GPCR activation assays used in both primary screening and compound profiling were as follows: binding assays - radiometric from PerkinElmer; β-arrestin recruitment or receptor internalization - chemiluminescence from DiscoveRx; label-free cellular changes & translocation - label-free readout from Corning; GTP Order this report by calling +1 888 391 5441 or Send an email to sales@reportsandreports.com with your contact details and questions if any. © ReportsnReports.com / Contact sales@reportsandreports.com

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